Leukocyte-platelet Rich Fibrin for Alveolar Ridge Preservation
Chile38 participantsStarted 2022-11-01
Plain-language summary
After tooth extraction, there is a subsequent bone loss as a part of the natural healing of the tissue. Up to 50% of bone loss occurs during the first three months after extraction, jeopardizing a possible implant treatment. Alveolar ridge preservation techniques reduce bone loss, allowing a future implant treatment. Different bone filling materials have been used with good clinical results. The second-generation platelet concentrates (L-PRF) have recently been shown to induce bone regeneration when filling the socket after extraction, with significant biological and economic advantages. The hypothesis of this study is to test whether or not the use of L-PRF in alveolar ridge preservation results in a non-inferior horizontal radiographic change compared with the combination of a xenogeneic bone substitute with a collagen matrix.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Periodontally healthy individuals with at least 18 years of age
✓. Good oral hygiene (BOP \& Pl ≤ 20%)
✓. Patients with a single failing premolar in the maxilla and mandible.
✓. With or without buccal plate after tooth extraction (similar cases in both groups)
✓. Surrounded by a mesial and distal natural tooth
✓. Capability to comply with the study procedures
✓. Informed Consent as documented by signature
Exclusion criteria
✕. Pregnant or lactating women
✕. Known or suspected non-compliance, drug or alcohol abuse
✕. Smokers (\>10 cigarettes/day)
What they're measuring
1
Bone socket horizontal and vertical changes evaluated using cbct ((cone beam computed tomography)
Timeframe: first cbct immediately after socket preservation surgery, second cbct 4 months after surgery, 12 months after the final restoration of the implant.