Sepsis, Severe

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Sepsis, Severe trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 34 trials

RecruitingNot Applicable

NCT03244293

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its u…

China20 participantsStarted 2014-01-01

Treatment: no intervention

RecruitingNot Applicable

NCT05993442

Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk…

NeoDeco is a pragmatic, multicenter, parallel-group, cluster-randomised hybrid effectiveness-implementation trial designed to evaluate the impact of implementin…

Greece3,080 participantsStarted 2024-05-28

Treatment: Optimised kangaroo care

RecruitingNot Applicable

NCT04203979

Sepsis: From Syndrome to Personalized Care

This is a prospective, observational study designed to examine the performance of biomarkers, molecular biological methods and other analysis in blood from pati…

Norway1,950 participantsStarted 2020-01-06

RecruitingNot Applicable

NCT04955210

A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children

1\. To research the current situation of severe infection in children in China, and to investigate the incidence, prognosis and disease burden of severe infecti…

China5,000 participantsStarted 2022-04-30

Treatment: Not applicable（Cohort study）

RecruitingNot Applicable

NCT04961580

PK/PD of Ceftazidime Avitbatan Sodium in Children With Severe Infection

Ceftazidime avitbatan sodium is a broad-spectrum antibiotic with an antimicrobial spectrum covering resistant gram-negative bacteria. Its use in pediatric inten…

China30 participantsStarted 2022-10-01

Treatment: Ceftazidime Avitbatan Sodium

RecruitingNot Applicable

NCT04850456

Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

The inflammatory storm in critically ill patients releases cytokines, causing systemic immune damage, which may be an important cause of multiple organ failure…

China200 participantsStarted 2024-10-01

All recent trials (100 shown)

WithdrawnPhase 3

NCT07492875

Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia

This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have sever…

Location not specified0Started 2026-04-15

Treatment: Nogapendekin alfa inbakicept (NAI), agenT-797

WithdrawnPhase 2

NCT07492888

Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or…

This Phase 2 study tests whether adding two immune therapies - nogapendekin alfa-inbakicept (NAI) and off-the-shelf iNKT cell infusions - to standard care can s…

Location not specified0Started 2026-04-15

Treatment: Nogapendekin Alfa-Inbakicept (NAI), Allogeneic invariant Natural Killer T (iNKT) Cells (AgenT-797)

Sepsis, Severe

Trial phase breakdown

Trial status

Actively recruiting — 34 trials

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk…

Sepsis: From Syndrome to Personalized Care

A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children

PK/PD of Ceftazidime Avitbatan Sodium in Children With Severe Infection

Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

All recent trials (100 shown)

Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia

Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or…

Trial phase breakdown

Trial status

Actively recruiting — 34 trials

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk…

Sepsis: From Syndrome to Personalized Care

A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children

PK/PD of Ceftazidime Avitbatan Sodium in Children With Severe Infection

Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

All recent trials (100 shown)

Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia

Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or…

De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis

Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock

T2 and SeptiCyte RAPID Duration Project

Changes in Host Gene Expression to Differentiate Between Systemic Inflammation and Infection After Major Surgery

Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study

Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine

Cohort Study of Chronic Liver Disease Complicated by Sepsis

I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)

COrporeal Compression at the ONset of Severe Sepsis and Septic Shock

Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro-…

Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial)

Mechanisms of Precise Immune Cell Phenotyping and Prognostic Prediction in Severe Infection

The Extended Study of Prevalence of Infection in Intensive Care IV

Virulence of Staphylococcus Lugdunensis in Severe Infections

REAnimation Low Immune Status Markers

Performance Evaluation of the Fujifilm Wako Beta-D-glucan Technique in the Diagnosis of Major Invasive Fungal Infections…

PAN-ICIS Study: ICIS for Early Detection of Infectious Complications in Pancreatic Surgery