Neonatal Hearing Loss

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Neonatal Hearing Loss trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 27 trials

RecruitingNot Applicable

NCT05355415

Adaptive Optics Imaging of Outer Retinal Diseases

The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina inclu…

United States100 participantsStarted 2021-08-27

Treatment: Adaptive optics imaging

RecruitingNot Applicable

NCT07548944

Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance

Retinitis pigmentosa and similar degenerative diseases of the retina lead to progressive loss of vision. TES therapy with the CE-marked OkuStim® System is a tre…

Germany30 participantsStarted 2026-04-20

Treatment: Transcorneal Electrical Stimulation using the OkuStim System

RecruitingPhase 4

NCT04152551

Effects of Bisphosphonates on OI-Related Hearing Loss

Osteogenesis Imperfecta-related hearing loss usually occurs in individuals with mild (type I) OI and is much earlier in onset than age-related hearing loss, wit…

United States100 participantsStarted 2019-11-02

Treatment: Risedronate Oral Tablet

RecruitingPhase 1/2

NCT06789445

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

Study OpCT-001-101 is a Phase 1/2a first-in-human, multisite, 2-part interventional study to evaluate the safety, tolerability, and the effect on clinical outco…

United States54 participantsStarted 2025-03-10

Treatment: OpCT-001, OpCT-001

RecruitingPhase 2

NCT06627179

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

The purpose of this Phase 2b study is to evaluate the safety and tolerability of ultevursen administered via intravitreal injection (IVT) in subjects with Retin…

United States81 participantsStarted 2024-12-11

Treatment: Intravitreal Injection of Ultevursen, No intervention, will not receive any active study intervention

RecruitingNot Applicable

NCT06475651

Characterization and Contribution of Genome-wide DNA Methylation (DNA Methylation Episignatures) in Rare Diseases With P…

It is necessary to define reference DNA Methylation Episignatures from fetal DNA. The hypotheses are: * It is possible to define reference DNA Methylation Epis…

France63 participantsStarted 2026-02-26

Treatment: Methylation analysis

All recent trials (100 shown)

CompletedPhase 2

NCT03717909

Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome

This trial aims to investigate the efficacy, safety and tolerability of sodium valproate in the treatment of patients with Wolfram syndrome. 70 paediatric and a…

France, Poland +2 more63 participantsStarted 2018-12-28

Treatment: Sodium Valproate 200Mg E/C Tablet, Sodium Valproate matched placebo

CompletedNot Applicable

NCT02204618

Cochlear Implantation in Single Sided Deafness and Asymmetrical Hearing Loss: a Cost/Utility Study.

The investigators assume that cochlear implants in this indication are not only effective but also cost-effective. The investigators' experimental protocol reli…

France160 participantsStarted 2014-10

Treatment: cochlear implantation, 6 months initial abstention

Neonatal Hearing Loss

Trial phase breakdown

Trial status

Actively recruiting — 27 trials

Adaptive Optics Imaging of Outer Retinal Diseases

Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance

Effects of Bisphosphonates on OI-Related Hearing Loss

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

Characterization and Contribution of Genome-wide DNA Methylation (DNA Methylation Episignatures) in Rare Diseases With P…

All recent trials (100 shown)

Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome

Cochlear Implantation in Single Sided Deafness and Asymmetrical Hearing Loss: a Cost/Utility Study.

Trial phase breakdown

Trial status

Actively recruiting — 27 trials

Adaptive Optics Imaging of Outer Retinal Diseases

Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance

Effects of Bisphosphonates on OI-Related Hearing Loss

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

Characterization and Contribution of Genome-wide DNA Methylation (DNA Methylation Episignatures) in Rare Diseases With P…

All recent trials (100 shown)

Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome

Cochlear Implantation in Single Sided Deafness and Asymmetrical Hearing Loss: a Cost/Utility Study.

Oral N-acetylcysteine for Retinitis Pigmentosa

Assessment of Patient Experience With Auto-Captioning Glasses in NF2-Related-Schwannomatosis

AMX0035 in Adult Patients With Wolfram Syndrome

Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan

OSIA System Bilateral Implantation Efficacy Evaluation in Children With Ear Aplasia

Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F

Palliative Care Needs of Children With Rare Diseases and Their Families

OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION)

Does Recessive Optic Atrophy Due to WFS1 Exist?

A Study to Determine the Long-Term Safety, Tolerability and Biological Activity of SAR421869 in Patients With Usher Synd…

A Strategic Approach to Safe and Effective Cochlear Implantation in Patients With CHARGE Syndrome

Mechanisms of Fecal Incontinence in Wolfram Syndrome

Safety and Efficacy of NPI-001 Tablets for RP Associated With Usher Syndrome

24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome

Alport Syndrome Treatments and Outcomes Registry

Auditory Neural Function in Implanted Patients With Usher Syndrome

North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2

Early Check: Expanded Screening in Newborns