Low Grade Glioma (LGG), High Grade Glioma (HGG)

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Low Grade Glioma (LGG), High Grade Glioma (HGG) trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

RecruitingPhase 1

NCT05538130

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced So…

The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatmen…

United States124 participantsStarted 2022-11-30

Treatment: PF-07799544, PF-07799933

RecruitingNot Applicable

NCT07042620

A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery

The objective of this clinical investigation is to assess the safety and performance of the SonoClear® System. Performance will be assessed by analysis of the c…

Germany15 participantsStarted 2026-02-09

Treatment: SonoClear(R) System

RecruitingPhase 2

NCT05503797

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with locally advanced or metastatic solid tumors, o…

United States254 participantsStarted 2023-02-21

Treatment: Plixorafenib

All recent trials (8 shown)

Active — Not RecruitingPhase 1/2

NCT04201457

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

This phase I/II trial is designed to study the side effects, best dose and efficacy of adding hydroxychloroquine to dabrafenib and/or trametinib in children wit…

United States57 participantsStarted 2020-01-17

Treatment: Dabrafenib, Trametinib

CompletedPhase 1

NCT02473380

Fluorescence Spectroscopy Guided Surgery

Intraoperative surgical fluorescence microscopy is a useful technique for the surgical resection of glioma. However the accuracy of this method is limited by it…

France11 participantsStarted 2015-08

Treatment: Fluorescence spectroscopy guided surgery

Low Grade Glioma (LGG), High Grade Glioma (HGG)

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced So…

A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

All recent trials (8 shown)

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Fluorescence Spectroscopy Guided Surgery

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced So…

A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

All recent trials (8 shown)

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Fluorescence Spectroscopy Guided Surgery

Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation…

Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Ca…

Confocal Laser Endomicroscopy for Brain Tumors