Confocal Laser Endomicroscopy for Brain Tumors

Inclusion Criteria: * Patients older than 18 years old * Clinical signs and history of the disease in favor of a HGG, LGG * MRI study in favor of a HGG, LGG, meningioma or brain metastasis * Affiliated to or beneficiary of a social security system (or equivalent). * Patients who have provided written informed consent for the study Exclusion Criteria: * \- Allergy to fluorescein * Previous life-threatening allergic reactions and known hypersensitivity * Pregnant or lactating or not using effective contraception; * Restricted renal function define by a creatinine clearance \< 30ml/min * Patients under a beta-blockers treatment * Contraindication to do an MRI (pace-maker) * Contraindication to the use of 5-ALA : known hypersensibility to 5-ALA or to porphyrin, acute or chronic porphyria * Minor or adult ward of court (under guardianship or trusteeship) * No affiliation to a social security system (or equivalent). * Patients who express opposition to participation in the study.