Human Papillomavirus Type 16

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Human Papillomavirus Type 16 trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 27 trials

RecruitingPhase 2

NCT07454915

PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia

The purpose of this Phase 2 study is to compare the effects of administering the PVX4 combination device biologic product (pBI-4 DNA vaccine via electroporation…

United States, Taiwan138 participantsStarted 2026-04-01

Treatment: PVX4 Combination Product, Placebo Control

RecruitingPhase 2

NCT04852328

Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patie…

This is a phase 2 trial to assess the safety and tolerability of three schedules of CUE-101 administered in the neoadjuvant phase before standard of care (SOC)…

United States30 participantsStarted 2021-12-06

Treatment: CUE-101

RecruitingPhase 2

NCT07209189

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-esca…

The NeoScorch HN study is a single institution multisite phase II trial including 3 cohorts of 25 patients each for patients with newly diagnosed locoregionally…

United States75 participantsStarted 2026-02-18

Treatment: Toripalimab + Chemotherapy, Toripalimab

RecruitingPhase 3

NCT05581121

PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer

This is an international, multicenter and randomized open-label phase III study designed to demonstrate, in patients with stage IIIC1 cervical cancer, whether p…

Czechia, France510 participantsStarted 2023-12-20

Treatment: Standard treatment: Control arm, Experimental arm

RecruitingPhase 2/3

NCT04534205

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembroliz…

An open-label, controlled, multi-site, interventional, 2-arm, Phase II/III trial of BNT113 in combination with pembrolizumab vs pembrolizumab monotherapy as fir…

United States350 participantsStarted 2021-01-07

Treatment: BNT113, Pembrolizumab

RecruitingPhase 2

NCT07407569

Developing a First-void Urine-based Infection Model to Study HPV-specific Antibody-virion Interaction Before and After H…

The current study is an open-label, non-randomized, longitudinal exploratory trial using the licensed Gardasil 9 (9vHPV) vaccine in an off-label context to inve…

Belgium50 participantsStarted 2026-03-25

Treatment: Gardasil 9 (2 dose regimen)

All recent trials (100 shown)

CompletedPhase 2

NCT03603808

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

This phase II trial studies the use of human papillomavirus (HPV) deoxyribonucleic acid (DNA) plasmids therapeutic vaccine VGX-3100 (VGX-3100) and electroporati…

United States44 participantsStarted 2018-09-21

Treatment: Electroporation, HPV DNA Plasmids Therapeutic Vaccine VGX-3100

Active — Not RecruitingPhase 1/2

NCT05108870

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

Doctors leading this study hope to learn about the safety and effectiveness of combining medications HB-201 and HB-202 (also known as TheraT® vectors) with chem…

United States35 participantsStarted 2022-08-22

Treatment: HB-201, HB-202

Human Papillomavirus Type 16

Trial phase breakdown

Trial status

Actively recruiting — 27 trials

PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia

Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patie…

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-esca…

PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembroliz…

Developing a First-void Urine-based Infection Model to Study HPV-specific Antibody-virion Interaction Before and After H…

All recent trials (100 shown)

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

Trial phase breakdown

Trial status

Actively recruiting — 27 trials

PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia

Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patie…

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-esca…

PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembroliz…

Developing a First-void Urine-based Infection Model to Study HPV-specific Antibody-virion Interaction Before and After H…

All recent trials (100 shown)

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

Extended Follow-up of Women Who Received One, Two, and Three Doses of the HPV Vaccine in the Costa Rica Vaccine Trial (C…

Evaluation of NWRD09 for Female Participants With Persistent HPV16 Infection

CUE-101with Pembrolizumab for LA-HPV+HNSCCs

HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA

Study on the Safety, Humoral Immune Response, and Memory B Cell Response Characteristics of Sequential 9-Valent HPV Vacc…

A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomaviru…

Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Safety and Efficacy of Allogeneic HPV-specific T Cells in Adults With Recurrent or Metastatic HPV16+ Cancers

Negative HPV Test Results on Infinity/GeneXpert® With the Presence of a Late Amplification Signal: What Does This Mean ?…

Assessing Administration of pBI-11 Via Electroporation for the Treatment of Patients With HPV16/18+

E7 TCR T Cells for Human Papillomavirus-Associated Cancers

Clinical Trial Assessing the Safety and Immunologic Correlates of Heterologous Prime-Boost With pNGVL4a-Sig/E7(Detox)/HS…

Extended Follow Up of Young Women in Costa Rica Who Received Vaccine for Human Papillomavirus Types 16 and 18 and Unvacc…

A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minima…

Study Assessing Reduced HPV Infectivity and Transmission in HPV-Positive Women Following Vaccination With 9vHPV

Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers

Safety and Feasibility of TA-CIN Vaccine in HPV16 Associated Cervical Cancer

A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma