Gastric Cancer, Gastroesophageal Junction Cancer

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Gastric Cancer, Gastroesophageal Junction Cancer trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 46 trials

RecruitingPhase 1

NCT04389632

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe fo…

United States1,006 participantsStarted 2020-06-08

Treatment: sigvotatug vedotin, pembrolizumab

RecruitingPhase 3

NCT07362186

LM-108 in Combination With Toripalimab Versus Paclitaxel Injection for the Treatment of Subjects With CCR8-Positive Gast…

This is a phase III， Multicenter, Randomized study， evaluating the efficacy and Safety of LM-108(an Anti-CCR8 mAb) in combination With Toripalimab Versus Paclit…

China400 participantsStarted 2026-04-30

Treatment: LM-108 in combination with Toripalimab, Paclitaxel injection intravenous infusion

RecruitingNot Applicable

NCT05334069

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing s…

United States2,000 participantsStarted 2022-08-18

Treatment: Questionnaire Administration, Biospecimen Collection

RecruitingNot Applicable

NCT07283939

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

This study seeks to learn whether using the PAGODA algorithm to guide chemotherapy dosing will lower the chance of unplanned delays during chemotherapy for canc…

United States420 participantsStarted 2026-02-13

Treatment: PAGODA algorithm, Oxaliplatin

RecruitingNot Applicable

NCT05993234

A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocar…

Trastuzumab deruxtecan (T-DXD) as monotherapy is indicated for the treatment of adult patients with advanced HER2-positive advanced gastric or gastroesophageal…

Austria257 participantsStarted 2023-12-05

Treatment: Trastuzumab deruxtecan

RecruitingPhase 1

NCT05872295

IKS014 in Advanced Solid Tumors That Express HER2

This study will evaluate the recommended dose for further clinical development, safety, tolerability, anti-tumor activity, immunogenicity, pharmacokinetics and…

United States, Australia165 participantsStarted 2023-09-14

Treatment: IKS014

All recent trials (100 shown)

Not Yet RecruitingNot Applicable

NCT07439484

Individually Tailored, Supervised, Remote Exercise Intervention to Improve Physical Function for Stage I-III Gastroesoph…

This clinical trial tests an individually tailored, supervised, remote exercise intervention to improve physical function for stage I-III gastroesophageal cance…

United States20 participantsStarted 2026-09-01

Treatment: Actigraphy, Biospecimen Collection

Active — Not RecruitingPhase 1/2

NCT04152499

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

A Phase I-II, First-in-Human Study of SKB264 (Sac-TMT; MK-2870) in Patients with Locally Advanced Unresectable/Metastatic Solid Tumors who are refractory to Ava…

United States1,410 participantsStarted 2020-02-28

Treatment: SKB264

Gastric Cancer, Gastroesophageal Junction Cancer

Trial phase breakdown

Trial status

Actively recruiting — 46 trials

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

LM-108 in Combination With Toripalimab Versus Paclitaxel Injection for the Treatment of Subjects With CCR8-Positive Gast…

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocar…

IKS014 in Advanced Solid Tumors That Express HER2

All recent trials (100 shown)

Individually Tailored, Supervised, Remote Exercise Intervention to Improve Physical Function for Stage I-III Gastroesoph…

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Trial phase breakdown

Trial status

Actively recruiting — 46 trials

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

LM-108 in Combination With Toripalimab Versus Paclitaxel Injection for the Treatment of Subjects With CCR8-Positive Gast…

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocar…

IKS014 in Advanced Solid Tumors That Express HER2

All recent trials (100 shown)

Individually Tailored, Supervised, Remote Exercise Intervention to Improve Physical Function for Stage I-III Gastroesoph…

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Up…

Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Intraperitoneal and Intravenous Paclitaxel Chemotherapy With Oral Capecitabine for Gastric Adenocarcinoma With Peritonea…

Study of SBRT/Olaparib Followed by Pembrolizumab/Olaparib in Gastric Cancers

A Study to Compare Zolbetuximab (IMAB362) and Chemotherapy With Placebo and Chemotherapy in Adults With Gastric Cancer.

A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Asso…

National Cancer Institute "Cancer Moonshot Biobank"

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal an…

A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced…

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expre…

Non-Invasive Detection of claudin18.2 in Pancreatic and Gastric/Gastroesophageal Junction Cancer by [68Ga]Ga-NODAGA-SNA0…

Oral Paclitaxel Plus Fruquintinib Verus Investigator's Choice in Second-Line Advanced Gastric Cancer

Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophagea…

A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With C…

A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors

A Phase 1b/2 Clinical Trial Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AUR103 Calcium in…

A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive…