A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive Locally Advanced Resectable Gastric Cancer of Adenocarcinoma of Gastroesophageal Junction

Inclusion Criteria: * Histologically confirmed gastric cancer or adenocarcinoma of GEJ * HER2-positive status defined as either IHC score of 3+ or IHC 2+ with amplification proven by in situ hybridization (ISH) as assessed by local review based on pretreatment endoscopic biopsies. * Clinical stage at presentation: cT3/T4a/T4b, or N+, M0 as determined by AJCC staging system, 8th edition * Availability of pretreatment tumor specimen for biomarker analysis by central lab * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Life expectancy \>= 12 weeks * Adequate hematologic and end-organ function * For female patients of childbearing potential, agreement (by patient) to remain abstinent (refrain from heterosexual intercourse) or to use highly effective form(s) of contraception during the treatment period and to continue its use for at least i) 5 months after the last dose of atezolizumab, ii) 7 months after the last dose of trastuzumab, or iii) 6 months after the last dose of capecitabine or oxaliplatin, whichever is longer. * For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom, and agreement to refrain from donating sperm Exclusion Criteria: * Stage IV (metastatic) or unresectable gastric/GEJ cancer determined by investigators * Prior systemic therapy for treatment of gastric cancer * History of malignancy other than GC within 5 years prior to screening, with the exception of malignancies with a negligible risk…