Familial Chylomicronemia Syndrome (FCS)

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Familial Chylomicronemia Syndrome (FCS) trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 1 trial

RecruitingEarly Phase 1

NCT07176923

CS-121 APOC3 Base Editing in FCS

This is an open-label, single-arm, dose-escalation Phase I clinical trial to evaluate the safety, tolerability, pharmacodynamics (PD), and pharmacokinetics (PK)…

China15 participantsStarted 2025-10-15

Treatment: CS-121

All recent trials (14 shown)

AVAILABLENot Applicable

NCT06796426

Treatment Protocol of Plozasiran in Adults With High-Risk Severe Hypertriglyceridemia (SHTG) and in Adults and Adolescen…

This is a treatment program for the use of plozasiran in adults (AROAPOC3-EAP-002) and adolescents (AROAPOC3-EAP-003) with familial chylomicronemia syndrome (FC…

United States

Treatment: Plozasiran

Active — Not RecruitingPhase 3

NCT05089084

Study of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS)

The purpose of AROAPOC3-3001 is to evaluate the efficacy and safety of ARO-APOC3 (plozasiran) in adult participants with familial chylomicronemia syndrome (FCS)…

United States75 participantsStarted 2021-12-14

Treatment: Plozasiran, Placebo

Familial Chylomicronemia Syndrome (FCS)

Trial phase breakdown

Trial status

Actively recruiting — 1 trial

CS-121 APOC3 Base Editing in FCS

All recent trials (14 shown)

Treatment Protocol of Plozasiran in Adults With High-Risk Severe Hypertriglyceridemia (SHTG) and in Adults and Adolescen…

Study of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS)

Trial phase breakdown

Trial status

Actively recruiting — 1 trial

CS-121 APOC3 Base Editing in FCS

All recent trials (14 shown)

Treatment Protocol of Plozasiran in Adults With High-Risk Severe Hypertriglyceridemia (SHTG) and in Adults and Adolescen…

Study of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS)

Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndr…

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome…

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicronemia Syndro…

Olezarsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS)

The APPROACH Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Patients With Familial Chylomicronemia Syndrom…

Volanesorsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS)

The Approach Open Label Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Chylomic…

Phase 2 Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Chylomicronemia Syndrome (FCS)

Extension to a Randomized, Double-blind, Placebo Controlled Study of LCQ908 in Subjects With Familial Chylomicronemia Sy…

A Randomized, Double-blind, Placebo Controlled Study to Assess Efficacy, Safety and Tolerability of LCQ908 in Subjects W…