Congenital Sensorineural Hearing Loss

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Congenital Sensorineural Hearing Loss trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 18 trials

RecruitingNot Applicable

NCT05355415

Adaptive Optics Imaging of Outer Retinal Diseases

The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina inclu…

United States100 participantsStarted 2021-08-27

Treatment: Adaptive optics imaging

RecruitingPhase 1/2

NCT05788536

A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otof…

Regeneron is conducting a study of an investigational new drug called DB-OTO. DB-OTO is a gene therapy that is being developed to treat children who have hearin…

United States30 participantsStarted 2023-06-27

Treatment: DB-OTO, DB-OTO

RecruitingNot Applicable

NCT07548944

Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance

Retinitis pigmentosa and similar degenerative diseases of the retina lead to progressive loss of vision. TES therapy with the CE-marked OkuStim® System is a tre…

Germany30 participantsStarted 2026-04-20

Treatment: Transcorneal Electrical Stimulation using the OkuStim System

RecruitingPhase 1/2

NCT06789445

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

Study OpCT-001-101 is a Phase 1/2a first-in-human, multisite, 2-part interventional study to evaluate the safety, tolerability, and the effect on clinical outco…

United States54 participantsStarted 2025-03-10

Treatment: OpCT-001, OpCT-001

RecruitingNot Applicable

NCT05402813

Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes

The purpose of this study is to follow the natural history of non-syndromic hearing loss caused by mutations in two genes (GJB2 or OTOF) in children up to 16 ye…

France180 participantsStarted 2022-11-18

Treatment: Pure Tone Audiometry Assessment, Quality of Life Questionnaires

RecruitingPhase 2

NCT06627179

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

The purpose of this Phase 2b study is to evaluate the safety and tolerability of ultevursen administered via intravitreal injection (IVT) in subjects with Retin…

United States81 participantsStarted 2024-12-11

Treatment: Intravitreal Injection of Ultevursen, No intervention, will not receive any active study intervention

All recent trials (52 shown)

Active — Not RecruitingPhase 3

NCT05537220

Oral N-acetylcysteine for Retinitis Pigmentosa

Retinitis pigmentosa (RP) is an inherited retinal degeneration caused by one of several mistakes in the genetic code. Such mistakes are called mutations. The mu…

United States485 participantsStarted 2023-10-11

Treatment: N-acetylcysteine, Placebo

By InvitationNot Applicable

NCT00341874

Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan

Objective: One objective of this study is to genetically map and identify mutated genes for human hereditary hearing loss. A second objective is to study the fu…

Pakistan24,000 participantsStarted 2000-03-16

Congenital Sensorineural Hearing Loss

Trial phase breakdown

Trial status

Actively recruiting — 18 trials

Adaptive Optics Imaging of Outer Retinal Diseases

A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otof…

Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

All recent trials (52 shown)

Oral N-acetylcysteine for Retinitis Pigmentosa

Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan

Trial phase breakdown

Trial status

Actively recruiting — 18 trials

Adaptive Optics Imaging of Outer Retinal Diseases

A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otof…

Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

All recent trials (52 shown)

Oral N-acetylcysteine for Retinitis Pigmentosa

Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan

A Study to Determine the Long-Term Safety, Tolerability and Biological Activity of SAR421869 in Patients With Usher Synd…

Safety and Efficacy of NPI-001 Tablets for RP Associated With Usher Syndrome

24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome

Alport Syndrome Treatments and Outcomes Registry

Analysis of Risk Factors of Neurodevelopmental Disorder in Deaf Infants Under Ten Months of Age.

Auditory Neural Function in Implanted Patients With Usher Syndrome

A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations

BF844 Safety and Pharmacokinetic Study in Healthy Volunteers

An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa

Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the…

Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of…

Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa

Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa

Study of SAR421869 in Participants With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B

Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene

Cytomegalovirus (CMV) Perilymphatic Fluid

Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants

Congenital Cytomegalovirus: Efficacy of Antiviral Treatment