Radiation Treatment of the Prostate That is Specially Adjusted for Each Person

Inclusion Criteria: * Histologically confirmed adenocarcinoma of the prostate * NCCN risk grouping of intermediate or high risk prostate cancer * Patients must be 18 years of age, or older on the day of signing informed consent and be willing and able to provide written informed consent/assent * Identifiable lesion within the epithelium of the prostate as determined by the treating radiation oncologist * Have a prostate imaging reporting and data system (PIRADS) 4 or 5 nodule noted on MRI * Have not received prior pelvic radiotherapy * Life expectancy greater than 10 years * ECOG performance status \<3 * Eligible for SBRT to the prostate Exclusion Criteria: * No identifiable lesion within the prostate on 3T MRI * Prior trans-urethral resection of the prostate * Non-adenocarcinoma histology * Meeting criteria for very high-risk risk or node positive prostate cancer * Active inflammatory bowel disease * Evidence of metastatic disease on CT or bone scan * Declined radiotherapy * Unlikely to be available for all follow-up appointments * Having received androgen deprivation therapy or 5-alpha reductase therapy prior to trial therapy * Extensive disease in the posterior prostate or aberrant anatomy that makes the safe delivery of boost irradiation not feasible * Unable to understand or sign a study consent form after use of interpreter if required * Has a relative contraindication to radiotherapy including systemic lupus erythematosus, TNM deficiency or scleroderma * Unable to t…