PASCAL Precision-GDMT Registry

Inclusion Criteria: * Participants of age ≥ 18 years * ≥ severe tricuspid regurgitation * LVEF \< 50% * Written informed consent of the patient or her/his legal representative * Patient understands the purpose, the potential risks as well as benefits of the trial and is willing to participate in all parts of the follow-up * Planned follow-up within a dedicated heart failure clinic as part of routine care. Exclusion Criteria: * Anatomy unsuitable for TEER as determined by local heart team * severe mitral regurgitation (defined as an EROA\>40 mm2) treated (surgically or percutaneously) less than 3 months prior * severe left ventricular dysfunction (defined as an LVEF \<20%) * systolic pulmonary artery pressure \>70 mmHg (right heart catheterization) * prior tricuspid valve intervention * severe leaflet degeneration or tricuspid valve anatomy precluding successful device placement * primary tricuspid valve disease * COPD requiring home oxygen therapy * active endocarditis, or recent episode within 4 weeks of discontinuation of antibiotic therapy * participants with unstable hemodynamic condition * significant co-morbidities resulting in an expected less than 12-month life expectancy * The presence of other anatomic or comorbid conditions or other medical, social or psychological conditions that in the investigators' opinion could limit the subject's ability to participate in the clinical study and its follow-up. * Participants under judicial protection, guardianship or curato…