Calming Minds Study (NCT07577401) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Calming Minds Study
United States500 participantsStarted 2026-06-08
Plain-language summary
The goal of this study is to understand why certain treatments help people reduce repetitive negative thinking (RNT), which is common in many mental health problems. We want to:
1. Figure out what actually causes repetitive negative thinking to decrease when people use cognitive-behavioral therapy (CBT).
2. Find out which parts of RNT-focused CBT are the most important - the parts that truly make a difference in reducing RNT.
The main result we will look at is how much a person's repetitive negative thought patterns change from the start of the study to the end of treatment (16 weeks). We will measure this using the Perseverative Thinking Questionnaire at baseline and week 16.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 18+ years
* Able to provide a valid Imperial Valley College email address
* Access to a suitable smartphone/device (iPhone 8+ running iOS 16.4 or higher, or Android version 8 or higher)
* Access to internet
* Elevated repetitive negative thought (RNT) based on scores from Ruminative Response Scale Brood subscale (RSS-brood) and Penn State Worry Questionnaire (PSWQ)
Exclusion Criteria:
* Concurrent psychotherapy
* Self-reported current or past diagnosis or treatment for Psychosis
* Self-reported current or past diagnosis or treatment for Bipolar disorder
* Self-reported current or past diagnosis or currently receiving, or waiting to receive, treatment for substance abuse/dependence
* Self-reported current diagnosis or currently receiving, or waiting to receive, treatment for alcohol abuse/dependence
* Antidepressant/anxiolytic medication that has changed in dose or nature in last 6 weeks
* Current severe PTSD defined as measured by the adapted International Trauma Questionnaire
* Active suicidal thoughts or self-harm
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Perseverative Thinking Questionnaire score from baseline to post-intervention