CompletedNot Applicable

EWSs and 28-Day Mortality in Geriatric ED Patients

Turkey (Türkiye)2,744 participantsStarted 2025-07-01

Plain-language summary

This prospective observational cohort study evaluated the prognostic performance of commonly used early warning scores for predicting 28-day all-cause mortality among geriatric patients presenting to the emergency department with non-traumatic conditions. Patients aged 65 years and older were consecutively screened during the study period. Demographic characteristics, comorbidities, vital signs, level of consciousness, blood gas parameters, complete blood count parameters, frailty status, and early warning scores were recorded at emergency department presentation or within the first hour of admission. The evaluated scoring systems included National Early Warning Score (NEWS/NEWS2), Modified Early Warning Score (MEWS), quick Sequential Organ Failure Assessment (qSOFA), Rapid Emergency Medicine Score (REMS), Cardiac Arrest Risk Triage (CART), and Hamilton Early Warning Score (HEWS) score. The primary outcome was 28-day all-cause mortality. The study also examined whether age, comorbidity burden, frailty, laboratory markers, and hemodynamic parameters were independently associated with 28-day mortality in this population.

Who can participate

Age range

65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Participants will be eligible for inclusion if they meet all of the following criteria: * Age 65 years or older * Presentation to the emergency department during the study period * Non-traumatic emergency department presentation * Availability of clinical data required for early warning score calculation * Availability of 28-day follow-up data * Written informed consent provided by the patient or, when applicable, by a legal representative Exclusion Criteria: Participants will be excluded if they meet any of the following criteria: * Trauma-related presentation * Insufficient clinical data for calculation of early warning scores * Incomplete 28-day follow-up data * Presentation in cardiac arrest * Death within the first hour after emergency department presentation * Known hematologic malignancy * Presentation for palliative support only * Inability to obtain informed consent from the patient or a legal representative

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Discriminatory Performance of Early Warning Scores for 28-Day Mortality

Timeframe: At emergency department presentation, with outcome assessment at 28 days

Trial details

NCT IDNCT07577349

SponsorHaseki Training and Research Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-01-29

View on ClinicalTrials.gov More Mortality trials