A Study to Learn if a Medicine Called Itraconazole Changes How the Body Processes the Study Medic… (NCT07575945) | Clinical Trial Compass
Active — Not RecruitingPhase 1
A Study to Learn if a Medicine Called Itraconazole Changes How the Body Processes the Study Medicine PF-08642534 in Healthy Adults.
United States14 participantsStarted 2026-05-05
Plain-language summary
The purpose of this study is to learn if a medicine called itraconazole changes how the body processes the study medicine (PF-08642534) in healthy adults.
This study is seeking healthy participants (men or women) who:
* are aged 18 to 65 years of age
* are confirmed to be healthy by their medical history and medical tests
* have body mass index (BMI) of 16 to 30 kilograms per meter squared
* have a total body weight of more than 50 kilograms.
Participants will receive single doses of the study medicine (PF-08642534) with and without itraconazole.
The total planned time of participation is about 12 weeks. The study consists of:
* a screening period of up to 28 days before taking study drug
* about 4 weeks of staying in the study clinic
* a follow-up contact that will occur 28 to 35 days after taking itraconazole the last time.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria:
* Generally healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, blood pressure, pulse rate and standard 12-lead electrocardiogram (ECG).
* Body Mass Index (BMI) of 16-30 kilograms per meter squared, inclusive, and a total body weight greater than 50 kilograms (110 pounds).
Exclusion criteria:
* Evidence or history of clinically significant disease
* Specified abnormalities in safety assessments at Screening
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
PF-08642534 Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast)