Continuous intravenous antibiotic infusion using elastomeric pumps is well established in adult care and has been shown to be effective, safe, and cost-efficient, particularly for beta-lactams and vancomycin. In pediatric outpatient parenteral antimicrobial therapy (p-OPAT), home intravenous treatment is feasible and safe, improves quality of life, and reduces hospital stays and healthcare-associated infections. Elastomeric pumps offer practical advantages, including portability, ease of use, fixed infusion rates, and reduced drug handling, although they are limited by fixed flow rates and drug stability. This prospective study at Tampere University Hospital (Tays) will evaluate the safety and cost-effectiveness of 24-hour continuous antibiotic infusions in children between January 2026 and January 2029. Eligible pediatric patients requiring intravenous antimicrobial treatment and suitable for home care will be included. Indications include serious bacterial infections such as bacteremia, osteomyelitis, septic arthritis, neutropenic fever, cystic fibrosis-related infections, and foreign body infections. The study antibiotics are benzylpenicillin, cloxacillin, piperacillin/tazobactam, and vancomycin, administered via CE-approved infusion devices for home use. Children will receive continuous infusion either initially in hospital or directly from the emergency department if appropriate, with treatment duration and dosing comparable to standard intermittent regimens. Outcomes include safety, feasibility, cost-effectiveness, and patient-reported quality of life measured using PedsQLâ„¢. The study aims to determine whether continuous infusion can optimize pediatric antimicrobial care and healthcare resource utilization. Results will be published in peer-reviewed international journals.
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Cost of treatment
Timeframe: From hospitalization to the end of the continuous antibiotic infusion
Duration of fever
Timeframe: From the beginning of the disease to the end of the continuous antibiotic infusion
Change in C-reactive protein (CRP) mg/ml
Timeframe: From hospitalization to the end of the continuous antibiotic infusion
Concomitant medications
Timeframe: From hospitalization to the end of the continuous antibiotic infusion
Parental absence from work (in days)
Timeframe: From hospitalization to the end of the continuous antibiotic infusion
Distance from home to hospital (in kilometers)
Timeframe: In the beginning of the study
Duration of antibiotic treatment (in days)
Timeframe: From hospitalization to the end of the continuous antibiotic infusion, up to one month
Safety, measured with adverse events
Timeframe: Assessed from study initiation up to three months thereafter
Emergency or clinic visits
Timeframe: Assessed from discontinuation of continuous antibiotic infusion up to one month thereafter