Allogeneic Dental Pulp Stem Cells for the Treatment of Periodontitis

Inclusion Criteria: * Disease Diagnosis: Clinically diagnosed with chronic periodontitis (typically Stage III or IV according to the latest periodontal disease classification). * Target Tooth Requirements: At least two non-adjacent periodontal pockets with a Probing Pocket Depth (PPD) ≥5 mm. * Clinical Attachment Level (CAL) loss ≥3 mm. * Evidence of significant alveolar bone resorption on X-ray or CBCT (bone loss exceeding one-third of the root length). * Age and General Condition: Typically aged 18-70 years, in good general health, and able to complete the 12-month follow-up. * Oral Hygiene Awareness: Subjects are willing to receive conventional periodontal basic treatment (SRP) and demonstrate a good willingness to maintain oral hygiene (e.g., plaque index controlled at a low level). Exclusion Criteria: * Systemic Diseases: Presence of severe, uncontrolled systemic diseases (e.g., diabetes with HbA1c \>7%, active hepatitis, tuberculosis). History of malignancy or immunodeficiency diseases (due to the proliferative potential of stem cells, cancer risk must be strictly excluded). * Local Interfering Factors: Target teeth with severe mobility (Grade III mobility) or non-restorable residual crowns/roots. Received periodontal surgical treatment or systemic antibiotics within the past 3 months. * Special Populations and Habits: Heavy smokers (typically defined as smoking \>10 cigarettes per day), as smoking significantly inhibits the regenerative effect of stem cells and loca…