Efficacy and Safety Evaluation of iNstroke 5F Aspiration Catheter for Thrombectomy

Inclusion Criteria: * Subjects aged ≥ 18 years. * Subjects able to be treated (i.e., defined by groin puncture time) within 24 hours of symptom onset or last time seen well. * Occlusion in a large or proximal medium vessel (M1, proximal M2, A2 or P2) identified by magnetic resonance angiography (MRA) or computed tomography angiography (CTA). * Baseline NIHSS score ≥ 6 assessed before the procedure. * Pre-stroke mRS score ≤ 2. * Subjects with an ASPECTS score ≥ 6. * Informed consent obtained in accordance with the applicable country-specific regulations and as approved by the Ethics Committee (EC). * France-specific inclusion criteria: As applicable under French law, subjects affiliated with a health social security scheme or equivalent. Exclusion Criteria: * Severe comorbidity and/or shortened life expectancy that will likely prevent improvement or follow up or that will render the procedure unlikely to benefit the patient. * Severe allergy to contrast media. * Women of child-bearing potential. * Subjects with intracranial atherosclerotic occlusive disease or extra- or intracranial dissection. * Medical history of thrombocytopenia (Platelets \<100,000). * Subjects with tandem occlusions (evidence of complete occlusion, high-grade stenosis or arterial dissection in the extracranial or petrous segment of the internal carotid artery). * Subjects with occlusions in multiple vessels. * Subjects with cancer who have a life expectancy of less than 6 months. * Pre-existing neurolo…