This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy. Surgical stress involves complex hemodynamic, endocrine, and inflammatory responses that may negatively impact postoperative recovery. Patients will be randomized to either anesthesia guided by conventional clinical and hemodynamic parameters or anesthesia additionally guided by CoreSys-derived indices of consciousness, nociception, and stress activity. The primary objective is to assess whether CoreSys-guided anesthesia attenuates stress biomarkers, including interleukin-6 (IL-6), cortisol and glycemia.
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Change in interleukin-6 (IL-6) levels
Timeframe: Baseline (pre-induction), end of surgery, and 24 hours postoperatively
Change in cortisol levels
Timeframe: Baseline (pre-induction), end of surgery, and 24 hours postoperatively
Change in blood glucose levels
Timeframe: Baseline (pre-induction), end of surgery, and 24 hours postoperatively