Effects of Adolescent Synaptic Pruning (NCT07569718) | Clinical Trial Compass
By InvitationNot Applicable
Effects of Adolescent Synaptic Pruning
United States60 participantsStarted 2026-01-09
Plain-language summary
The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based measures. This will inform youth MRI studies to understand neurotypical brain development that can help identify abnormal trajectories as in mental illness.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Males or females between 18-26 years of age, AND currently enrolled in the Parent Project (R01MH067924)
Exclusion Criteria: (these exclusion criteria are outlined in the Parent Project)
* Head injury with loss of consciousness over an hour.
* A vision problem or eye movement problem (such as lazy eye, double vision, blurred vision, or color blindness).
* A learning disability and/or ever had an Individualized Education Plan (IEP) in school.
* Significant neurological or metabolic illness: Epilepsy, Meningitis, Encephalitis, Diabetes, Huntington's disease.
* Diagnosed with a psychiatric disorder.
* Participants with, or with a first degree relative, having a DSM IV Axis l psychiatricdisorder.
* Metal implants or ferromagnetic objects contained within the body which may interfere with the MRI scan (but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant.) Dental fillings do not present a risk for MRI. If there is a possibility of metal being present in the participant's body, the participant will be excluded from the study.
* Weight more than 250 pounds.
* Claustrophobia or uncomfortable in small spaces.
* \<70% on the Achenbach scale (either from Youth Self Report (YSR) or Adult Self Report (ASR)).
* IQ \< 80 or IQ \> 130.
* Pregnancy or lactation, lack of effective birth control during 15 days before the scans.
* Currently employed as radiation worker; or participation in radioactive…
What they're measuring
1
Non-invasive quantification of synaptic pruning
Timeframe: The PET-CT scan will be within approximately 30 days of the parent study MRI.
2
Non-invasive quantification of synaptic pruning
Timeframe: The PET-CT scan will be within approximately 30 days of the parent study MRI.