In Vivo Noradrenergic System and Aging (NCT07569120) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
In Vivo Noradrenergic System and Aging
France165 participantsStarted 2026-07
Plain-language summary
The main goal of this research proposal is to provide, for the first time in humans, a wider understanding of the role of the noradrenergic system both in health and illness (here Parkinson's disease) through the use of a newly developed radiotracer visualizing alpha2C-ARs (\[11C\]ORM-13070) combined with a cutting-edge technology, the hybrid PET/MRI scanner. The secondary aim will be to determine whether the expected age- and PD-related changes in the noradrenergic system are paralleled by changes in neuropsychological performances (i.e. cognitive, motor and/or olfactory abilities).
Who can participate
Age range20 Years – 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for the healthy controls:
* Age between 20 years and 80 years
* Weight between 40kg and 100kg
* Without neurologic or psychiatric history
* Without head trauma history including loss of consciousness superior to 30 minutes.
* With highly effective contraception for women of childbearing age
* Affiliated to a social security or similar scheme
* Not subject to any legal protection measures
* Participant must have signed an informed consent document
Inclusion Criteria for the patients with Parkinson's disease:
* Age between 40 years and 80 years
* Weight between 40kg and 100kg
* With an idiopathic Parkinson's disease (Dopa-sensitive)
* Without head trauma history including loss of consciousness superior to 30 minutes.
* Without associated neurological pathology
* With highly effective contraception for women of childbearing age
* Affiliated to a social security or similar scheme
* Not subject to any legal protection measures
* Participant must have signed an informed consent document
Exclusion Criteria for all participants :
* Subject receiving (or having received in the last month) somatic medication with cerebral or psychological effects (e.g., antihistamines), see list in Appendix1
* Subjects with a current or past dependence on alcohol or any other addictive substance according to DSM-IV-TR criteria, with the exception of nicotine and caffeine; -
* Subjects already participating in another biomedical research project or who have participated in a stud…