Not Yet RecruitingPhase 2

Taurine for the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma

China130 participantsStarted 2026-05-06

Plain-language summary

This clinical trial aims to understand whether taurine can prevent and reduce severe radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing radiotherapy.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion criteria

✓. Age 18-70 years.
✓. Histologically confirmed newly diagnosed non-keratinizing nasopharyngeal carcinoma (WHO classification).
✓. Non-metastatic nasopharyngeal carcinoma (Stage I-III) according to the AJCC 9th edition staging system.
✓. Scheduled to receive radical intensity-modulated radiotherapy (IMRT).
✓. No prior history of anti-cancer treatment.
✓. ECOG performance status 0-1; adequate organ function within 2 weeks before enrollment; Hematology: hemoglobin \> 90 g/L; absolute neutrophil count \> 1.5×10⁹/L; platelet count \> 100×10⁹/L. Biochemistry: total bilirubin ≤ 1.5×ULN; ALT, AST ≤ 2.5×ULN; ALP ≤ 2.5×ULN; creatinine clearance ≥ 50 mL/min.
✓. For patients with abnormal ECG or prior cardiovascular disease, additional cardiac function tests and echocardiography must be normal.
✓. Provided written informed consent and willing to comply with study visits, treatment, laboratory tests, and other protocol requirements.

Exclusion criteria

✕. Known intolerance or hypersensitivity to taurine or its excipients.
✕. Conditions that interfere with oral drug administration (e.g., dysphagia, chronic diarrhea, intestinal obstruction).
✕. Prior history of malignant tumor.
✕

What they're measuring

Incidence of Severe Radiation-Induced Oral Mucositis

Timeframe: From the start of radiotherapy to 4 weeks after completion of radiotherapy

Trial details

NCT IDNCT07567742

SponsorSun Yat-sen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-03-30

Contact for this trial

Jun Ma

+86-20-87343469 yangkb@sysucc.org.cn

View on ClinicalTrials.gov More Oral Mucositis (Ulcerative) Due to Radiation trials