Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Pa… (NCT07567053) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study
United States60 participantsStarted 2026-05-01
Plain-language summary
This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP). By applying 6-Hz primed low and high-frequency rTMS and measuring brain responses through TMS-EEG, the study aims to enhance neural plasticity and motor recovery. The goal is to promote faster rehabilitation and reduce long-term healthcare needs.
Who can participate
Age range6 Years – 18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria (CP):
* Aged 6 - 18 years,
* A confirmed diagnosis of CP by a specialized professional (pediatric neurologist, PM\&R physician, neonatal developmental specialist, or neonatologist) is a prerequisite for participation,
* Classified as high functioning (Level I, II, or III) according to the Gross Motor Function Classification System (GMFCS),
* Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,
* Preserved vision and hearing (with or without correction).
Inclusion Criteria (TD):
* Aged 6 - 18 years
* Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,
* Preserved vision and hearing (with or without correction).
Exclusion Criteria (CP):
* Syndromic or genetic associations,
* History of trauma or brain surgery,
* Inability to remain still,
* History of Epilepsy,
* Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,
* Modified Ashworth Scale: Shoulder, elbow, and wrist scores more than 3,
* Limb contractures caused by injury,
* Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,
* Any congenital brain abnormality shown on a traditional brain MRI,
* A cast, splint, or recent surgery on the affected limb,
* Botulinum toxin/phenol block applied to the afflicted limb within the last six months or anticipated during the research perio…
What they're measuring
1
Change on TMS-evoked potentials (TEPs)
Timeframe: Within the end of 4 weeks and 1-month follow-up of sham/real rTMS