Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and… (NCT07565909) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression
72 participantsStarted 2026-06
Plain-language summary
In this single-arm Phase 2 study, the researchers are assessing the feasibility of the group retreat format for clinicians and explores different 'doses' of preparation. A sequential dose-escalation design is used. The study will recruit healthcare clinicians (physicians, nurses, nurse practitioners, physician assistants) aged 25-70 years currently in clinical practice with moderate or greater symptoms of depression and loss of meaning during the past 5 years. Each participant will be in a group cohort of 8, and 3 cohorts will be tested at each dose level. The objectives are safety, feasibility, mechanism testing, and outcomes.
Who can participate
Age range25 Years – 70 Years
SexALL
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Inclusion criteria
✓. Healthcare clinicians (physicians, nurses, nurse practitioners, physician assistants) currently in clinical practice
✓. Age 25-70 years
✓. Loss of meaning single question "I used to find deep meaning in my work as a healthcare clinician, but during the past 5 years that sense of meaning has faded".
✓. PHQ-9 score ≥10 (moderate symptoms of depression)
✓. Ability to commit to all preparation sessions and retreat attendance
✓. English fluency sufficient for group participation
✓. Screening laboratory tests within acceptable limits, including liver function tests
✓. Negative urine drug screen for non-prescribed psychoactive medications.
Exclusion criteria
✕. Personal or first-degree family history of psychotic disorder or bipolar I disorder
✕
What they're measuring
1
Safety and Feasibility measures
Timeframe: 1 week, 1 month, and 3 months after the retreat.