Nanocrystalline Megestrol Acetate Versus Placebo for Anorexia in Patients With Unresectable Hepatocellular Carcinoma Receiving TACE Combined With Targeted and Immunotherapy

Inclusion Criteria: * Patients with unresectable primary hepatocellular carcinoma (HCC) confirmed by imaging or histopathology * No previous receipt of immunotherapy and/or targeted drug therapy * Child-Pugh score ≤ 7 * At least one measurable lesion per RECIST 1.1 criteria; lesions without prior radiotherapy, cryotherapy or other local treatment * Single intrahepatic lesion \< 10 cm, or fewer than 10 intrahepatic lesions with tumor burden \< 50% * Meet precachexia criteria: non-volitional weight loss ≤ 5% in 6 months, plus systemic inflammation (CRP \> 5 mg/L) or decreased appetite (FAACT-A/CS-12 score ≤ 37 points) * Meet cachexia criteria: accompanied by decreased appetite or systemic inflammation, with either non-volitional weight loss \> 5% in 6 months or BMI \< 18.5 kg/m² plus weight loss \> 2% * Voluntarily participate and sign informed consent * Age ≥ 18 years, male or female * Able to swallow tablets normally * ECOG performance status 0 or 1 * Life expectancy ≥ 12 weeks * Adequate major organ function without blood products or colony-stimulating factors within 14 days * Hematology: ANC ≥ 1.5×10⁹/L, Hb ≥ 80 g/L, PLT ≥ 50×10⁹/L * Liver function: TBIL ≤ 1.5×ULN, AST/ALT ≤ 5.0×ULN, ALB ≥ 28 g/L * Coagulation function: INR, PT or aPTT ≤ 1.5×ULN * Renal function: SCr ≤ 1.5×ULN or creatinine clearance ≥ 60 mL/min * Urine protein ≤ 1+ or 24-hour urine protein \< 1.0 g * Cardiac function: LVEF ≥ 50% * Females of childbearing potential with negative pregnancy test within 3 day…