Prehospital Point-of-Care Hs-Troponin I for Rule-Out of Acute Myocardial Infarction in Patients W… (NCT07563998) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Prehospital Point-of-Care Hs-Troponin I for Rule-Out of Acute Myocardial Infarction in Patients Without ST-Segment Elevation
500 participantsStarted 2026-05-15
Plain-language summary
People who call emergency medical services (EMS) with chest pain or other possible heart-related symptoms are often taken to hospital for further testing. However, only a small proportion of these patients are ultimately diagnosed with a serious heart condition such as a heart attack. This means that many patients undergo hospital transport and evaluation even though their risk is low.
In hospitals, a blood test called high-sensitivity cardiac troponin is commonly used to help diagnose or rule out heart attacks. It is not yet well established whether this type of test can be used safely and effectively earlier, in the prehospital setting.
This study will investigate whether it is feasible to measure high-sensitivity troponin in the ambulance and how well the test can identify patients at low risk of serious heart conditions. A small blood sample will be taken as part of routine care and analyzed using a portable device. The test result will not be used to guide treatment or decisions during the study.
The study will assess how well the test predicts heart-related events within 30 days and how practical it is to perform the test in real-life emergency settings. The results may help guide future research on how to improve early assessment and decision-making for patients with suspected heart disease.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older
* Assessed by one of the participating EMS units equipped for POCT sampling
* Presentation with symptoms suggestive of acute coronary syndrome
* Planned transport to hospital for further evaluation
Exclusion Criteria:
* ST-segment elevation on prehospital electrocardiogram
* Clinical condition requiring immediate life-saving intervention precluding study procedures
* Interhospital transport
* Prior inclusion in the study within 30 days
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial involves getting a high-sensitivity troponin blood test done by paramedics before even arriving at the hospital — how would that change my care compared to the standard approach of waiting for tests to be run in the emergency department?
2Since the trial is not yet recruiting, do you know when it might open and whether it would be worth waiting to see if I could participate, or should we proceed with standard evaluation now?
3The trial is tracking serious cardiac events like heart attacks over 30 days — what does that tell us about the kinds of risks involved in the approach being tested, and are there any concerns about ruling out a heart attack too early outside a hospital setting?
4This study is listed as Phase NA, which often means it's evaluating a diagnostic process rather than a new drug — can you help me understand what the actual difference in my experience would be if I were enrolled versus receiving usual care?
5If this prehospital troponin test were to suggest I'm low-risk and I'm not taken to the hospital right away, what safety nets would be in place to make sure something serious isn't missed, and how does that compare to what would happen with standard emergency care?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Major adverse cardiac events (MACE) within 30 days