Effect of Lemon Juice and Apple Cider Vinegar on Postprandial Blood Glucose and Satiety in Health… (NCT07563985) | Clinical Trial Compass
RecruitingNot Applicable
Effect of Lemon Juice and Apple Cider Vinegar on Postprandial Blood Glucose and Satiety in Healthy Individuals
Turkey (Türkiye)15 participantsStarted 2026-05-01
Plain-language summary
This clinical study aims to examine how acidic drinks (lemon juice and apple cider vinegar) affect blood sugar when consumed with a starchy food. The study focuses on healthy individuals and aims to understand whether these drinks can slow the rise in blood sugar after meals and affect feelings of fullness.
The main questions this study aims to answer are:
Do lemon juice or apple cider vinegar lower the rise in blood sugar after a meal? Do these drinks increase feelings of fullness? Do different amounts change their effects?
Researchers will compare lemon juice and apple cider vinegar to see which one is more effective.
Participants will:
Consume white bread in the morning on an empty stomach with one of the following drinks:
Water only Water with lemon juice (50 g or 100 g) Water with apple cider vinegar (10 g or 20 g) Have a one-week break between each test. Have their blood sugar measured at regular intervals for 3 hours after eating. Report their level of fullness using a simple scale.
This study explores whether simple and practical dietary choices can help manage blood sugar levels. The findings may support new, easy-to-apply nutrition strategies for managing diabetes and weight.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy male and female volunteers aged 18-35 years
* Body Mass Index (BMI) between 18.5 and 25.0 kg/m²
* Willingness to provide written informed consent
* Ability to comply with study procedures and fasting requirements
* No history of chronic metabolic, gastrointestinal, or endocrine diseases
Exclusion Criteria:
* Presence of any chronic disease (e.g., diabetes mellitus, cardiovascular disease, gastrointestinal disorders)
* Food allergies or intolerances to study foods (white bread, lemon juice, apple cider vinegar)
* BMI \<18.5 or \>25.0 kg/m²
* Regular participation in high-intensity physical activity (≥5 days/week)
* Current or recent (past 3 months) smoking or smoking cessation
* Use of any medication or supplements affecting glucose metabolism
* History of eating disorders
* Pregnancy, lactation, or menopause
* Female participants currently in menstruation period (testing will be postponed during menstruation days)
* Alcohol consumption within 24 hours prior to testing days
* Caffeine intake or major dietary changes on the day before testing
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postprandial Blood Glucose (mg/dL)
Timeframe: Baseline (0 min) to 180 minutes postprandial on each test day (with 1-week washout between interventions)
2
Incremental Area Under the Curve (iAUC)
Timeframe: Baseline (0 min) to 180 minutes postprandial on each test day
3
Total Area Under the Curve (AUC)
Timeframe: Baseline (0 min) to 180 minutes postprandial on each test day
4
Peak Blood Glucose Level (mg/dL)
Timeframe: Baseline (0 min) to 180 minutes postprandial on each test day