The goal of this clinical trial is to learn if a one-day course of antibiotics after appendectomy surgery works as well as a five-day course to prevent infections in children and adults (aged 10 years and older) with uncomplicated acute appendicitis (non-ruptured, non-gangrenous appendix). The main questions it aims to answer are: * Does a one-day antibiotic regimen result in a similar rate of surgical site infections, intra-abdominal abscesses, or death within 30 days after surgery compared to a five-day regimen? * What is the rate of hospital readmission, antibiotic-related side effects, and cost-effectiveness for each treatment duration? Researchers will compare participants receiving 24 hours of intravenous antibiotics to participants receiving 5 days of antibiotics (1 day intravenous followed by 4 days oral) to see if the shorter course is non-inferior (not meaningfully worse) to the longer standard course. Participants will: * Undergo appendectomy for uncomplicated acute appendicitis * Be randomly assigned to receive either one day or five days of postoperative antibiotics * Receive follow-up at 30 days after surgery, including a telephone call to check for infections, readmissions, or other complications * Allow study staff to collect information from their medical records regarding hospital stay, antibiotic side effects, and any need for reoperation or restarting antibiotics
Age range
10 Years – 60 Years
Sex
ALL
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Rate of Surgical Site Infection (SSI)
Timeframe: Within 30 days post-appendectomy
Rates of Intra-abdominal Abscess (IAA)
Timeframe: Within 30 days (± 3 days) post-appendectomy.
Rate of All-Cause Mortality
Timeframe: Within 30 days post-appendectomy