The goal of this observational study is to evaluate how blood donors' lifestyle and nutritional status influence the quality of packed red blood cells (pRBCs) during storage and their impact on patient safety in transfused neonates and postpartum women. The main questions it aims to answer are: 1. Are donor lifestyle and nutritional profiles associated with the development of storage lesions in pRBCs? 2. Do these donor-related factors influence clinical outcomes after transfusion in neonates and postpartum women? 3. Are storage lesion in pRBCs associated with clinical outcomes in transfused neonates and postpartum women? Researchers will compare pRBC units stratified according to donor lifestyle and nutritional profiles to determine differences in storage lesion biomarkers and post-transfusion clinical outcomes.
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Antioxidant capacity in stored blood units
Timeframe: From donation (baseline) to transfusion or end of storage (up to 42 days)
Oxidative damage in stored blood units
Timeframe: From donation (baseline) to transfusion or end of storage (up to 42 days)
Red blood cell membrane changes
Timeframe: From donation (baseline) to transfusion or end of storage (up to 42 days)
Hemolysis in stored blood units
Timeframe: From donation (baseline) to transfusion or end of storage (up to 42 days)
Patient safety
Timeframe: Within the first 24 hours post-transfusion and throughout hospitalization