RecruitingNot Applicable

Mavacamten Outcomes in Hypertrophic Cardiomyopathy (HCM) and the Associated Patient and Physician Experiences in the US

United Kingdom362 participantsStarted 2026-01-15

Plain-language summary

The purpose of this study is to understand the real-world clinical outcomes and treatment patterns of adults with obstructive hypertrophic cardiomyopathy (HCM) treated with mavacamten, and to understand patient and physician experiences with mavacamten treatment, in the US community-based practice

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Phase I: retrospective chart review For inclusion in the study, participants must meet ALL of the following criteria: * Are an adult aged 18 or over at baseline * Have a confirmed diagnosis of obstructive hypertrophic cardiomyopathy (HCM) * Have been prescribed mavacamten for obstructive HCM at one of the study sites between 28th April 2022 and 31st December 2024 * Have not ever been enrolled in any interventional clinical trial involving any cardiac myosin inhibitor (enrollment in observational studies is permitted) * Are not enrolled in any interventional clinical trial at study baseline Phase II: patient survey • Participants must meet all inclusion criteria of Phase I: retrospective chart review and be able to read and understand English and have access to computer or smartphone to complete the survey Exclusion Criteria: • None with the proviso that all inclusion criteria are met.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Participant blood pressure (both systolic and diastolic)

Timeframe: Baseline

Date of diagnosis of hypertrophic cardiomyopathy

Timeframe: Baseline

Hypertrophic cardiomyopathy genetic testing results

Timeframe: Baseline

Family history of hypertrophic cardiomyopathy

Timeframe: Baseline

Family history of Sudden Cardiac Death (SCD)

Timeframe: Baseline

Participant comorbidities (cardiovascular and non-cardiovascular )

Timeframe: Baseline

Type of prior surgeries and procedures

Timeframe: Baseline and up to week 24

Participant New York Heart Association (NYHA) class category

Trial details

NCT IDNCT07557498

SponsorBristol-Myers Squibb

Sponsor typeINDUSTRY

Study typeOBSERVATIONAL

Primary completion2026-12-14

Contact for this trial

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

855-907-3286 Clinical.Trials@bms.com

View on ClinicalTrials.gov More Obstructive Hypertrophic Cardiomyopathy (oHCM) trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Participant blood pressure (both systolic and diastolic)

Timeframe: Baseline

Date of diagnosis of hypertrophic cardiomyopathy

Timeframe: Baseline

Hypertrophic cardiomyopathy genetic testing results

Timeframe: Baseline

Family history of hypertrophic cardiomyopathy

Timeframe: Baseline

Family history of Sudden Cardiac Death (SCD)

Timeframe: Baseline

Participant comorbidities (cardiovascular and non-cardiovascular )

Timeframe: Baseline

Type of prior surgeries and procedures

Timeframe: Baseline and up to week 24

Participant New York Heart Association (NYHA) class category