Randomized Clinical Trial of Endovascular Treatment for Progressive Stroke With Vertebrobasilar A… (NCT07557485) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Randomized Clinical Trial of Endovascular Treatment for Progressive Stroke With Vertebrobasilar Artery Occlusion
China240 participantsStarted 2026-06-01
Plain-language summary
This multicenter, prospective, open-label randomized controlled trial with blinded assessment was designed to assess the efficacy and safety of endovascular treatment for progressive stroke due to vertebrobasilar artery occlusion.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Age ≥18 years.
✓. Acute ischemic stroke, with a National Institutes of Health Stroke Scale (NIHSS) score of \<10 at initial symptom onset, and no prior endovascular treatment.
✓. Stroke progression occurring from 24 hours to 14 days after initial symptom onset, defined as an NIHSS score of ≥10 with an increase of ≥4 points from baseline.
✓. Acute basilar artery occlusion or dominant vertebral artery occlusion with contralateral occlusion or hypoplasia, confirmed by CTA, MRA or DSA.
✓. Posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) of ≥6 and Pons-Midbrain Index (PMI) of ≤3 on CT or diffusion-weighted imaging (DWI).
✓. Randomization within 24 hours of stroke progression.
✓. Pre-stroke mRS score of 0-2.
✓. Provision of signed informed consent by the patient or their legal representative.
Exclusion criteria
✕. Any sign of intracranial hemorrhage (except microbleeds) on baseline brain imaging.
✕. Imaging confirms the progression of symptoms caused by intracranial hemorrhage, brain edema, or other clear causes.
✕. Extensive cerebellar infarction with significant mass effect or bilateral thalamic infarction on baseline neuroimaging.
✕
What they're measuring
1
The proportion of patients achieving modified Rankin Scale (mRS) score 0-3 at 90 days
. Presence of untreated intracranial aneurysm, intracranial tumor (except small meningioma and aneurysms \<3 mm in diameter), or intracranial arteriovenous malformation.
✕. Known or highly suspected chronic responsible artery occlusion.
✕. Presence of severe stenosis in the extracranial or intracranial segment of the responsible artery, arterial dissection, or excessive vascular tortuosity that may prevent successful delivery or navigation of endovascular devices.
✕. Known contraindication to contrast medium (except mild rash).
✕. Refractory hypertension not controlled by medication, defined as systolic blood pressure \>185 mmHg or diastolic blood pressure \>110 mmHg.