Randomized Clinical Trial of Endovascular Treatment for Progressive Stroke With Vertebrobasilar A… (NCT07557485) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Randomized Clinical Trial of Endovascular Treatment for Progressive Stroke With Vertebrobasilar Artery Occlusion
China240 participantsStarted 2026-06-01
Plain-language summary
This multicenter, prospective, open-label randomized controlled trial with blinded assessment was designed to assess the efficacy and safety of endovascular treatment for progressive stroke due to vertebrobasilar artery occlusion.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age ≥18 years.
. Acute ischemic stroke, with a National Institutes of Health Stroke Scale (NIHSS) score of \<10 at initial symptom onset, and no prior endovascular treatment.
. Stroke progression occurring from 24 hours to 14 days after initial symptom onset, defined as an NIHSS score of ≥10 with an increase of ≥4 points from baseline.
. Acute basilar artery occlusion or dominant vertebral artery occlusion with contralateral occlusion or hypoplasia, confirmed by CTA, MRA or DSA.
. Posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) of ≥6 and Pons-Midbrain Index (PMI) of ≤3 on CT or diffusion-weighted imaging (DWI).
. Randomization within 24 hours of stroke progression.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The proportion of patients achieving modified Rankin Scale (mRS) score 0-3 at 90 days
. Provision of signed informed consent by the patient or their legal representative.
Exclusion criteria
. Any sign of intracranial hemorrhage (except microbleeds) on baseline brain imaging.
. Imaging confirms the progression of symptoms caused by intracranial hemorrhage, brain edema, or other clear causes.
. Extensive cerebellar infarction with significant mass effect or bilateral thalamic infarction on baseline neuroimaging.
. Presence of untreated intracranial aneurysm, intracranial tumor (except small meningioma and aneurysms \<3 mm in diameter), or intracranial arteriovenous malformation.
. Known or highly suspected chronic responsible artery occlusion.
. Presence of severe stenosis in the extracranial or intracranial segment of the responsible artery, arterial dissection, or excessive vascular tortuosity that may prevent successful delivery or navigation of endovascular devices.
. Known contraindication to contrast medium (except mild rash).
. Refractory hypertension not controlled by medication, defined as systolic blood pressure \>185 mmHg or diastolic blood pressure \>110 mmHg.