Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic S… (NCT07556068) | Clinical Trial Compass
RecruitingNot Applicable
Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation
China129 participantsStarted 2026-04-20
Plain-language summary
This multicenter, prospective, observational diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90 days post-enrollment. The study aims to determine whether impaired cerebral autoregulation during thrombectomy can serve as an ultra-early biomarker for predicting futile recanalization in patients with acute ischemic stroke.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Age ≥ 18
✓. Clinical signs consistent with acute ischemic stroke with large vessel occlusion in the anterior circulation (intracranial segment of the internal carotid artery, middle cerebral artery M1 segment) demonstrated with CTA/MRA/DSA.
✓. NIHSS score ≥ 6 obtained prior to endovascular treatment.
✓. Modified Rankin Scale ≤ 1 prior to qualifying stroke.
✓. Acute ischemic stroke, undergone endovascular treatment within 24 hours of onset (time of stroke is the last known normal for wake-up stroke or with unknown onset time).with reaching the goal of mTICI grade 2b-3
✓. For patients with symptom onset within 6 hours: ASPECTS ≥ 3; for patients with symptom onset between 6 and 24 hours: age ≤ 80 years and ASPECTS ≥ 3.
✓. Patient/Legally Authorized Representative has signed the Informed Consent Form.
Exclusion criteria
✕. Baseline CT/MRI confirms the presence of multiple vascular territory acute strokes.
✕. Baseline CT/MRI confirms the presence of arterial dissection.
✕. Evidence of intracranial hemorrhage or hemorrhagic transformation before thrombectomy.
✕. Known allergies or intolerances to antiplatelet agents, anticoagulation drugs, iodinated contrast and/or anesthetics.
What they're measuring
1
The sensitivity, specificity and area under the receiver operating characteristic curve for percentage of Modified Rankin scale 0-2
Timeframe: Month 3
Trial details
NCT IDNCT07556068
SponsorBeijing Shijitan Hospital, Capital Medical University
. Severe infection (e.g. sepsis) or multiple organ failure.
✕. Known hereditary or acquired hemorrhagic diathesis or coagulation factor deficiency; oral anticoagulant therapy with INR \> 3; or use of a factor Xa inhibitor within the preceding 48 hours with an abnormal aPTT.