Yishen Shujin Decoction for Fibromyalgia Syndrome

Inclusion Criteria: * Patients with primary fibromyalgia who met the FM classification criteria established by the American College of Rheumatology in 2016. * TCM syndromes of liver qi stagnation and yin blood insufficiency, or hepatic and renal yin deficiency. * aged 18 years old and above, 75 years old and below. * pain VAS score ≥ 4. * not taking the treatment of FM drugs or not using the treatment of FM program for more than 1 month. * Sign the informed consent. Exclusion Criteria: * Patients with severe depression or anxiety ; * patients with cardiovascular and cerebrovascular, liver, kidney and hematopoietic system and other serious primary diseases and thrombotic diseases ; * Lactating or pregnant women ; * patients with allergy to therapeutic ingredients ; * patients with severe pain caused by other diseases ( such as diabetic pain or postherpetic neuralgia ) ; * patients who have recently participated in clinical trials of the same indications ； * Patients who are male, right-handed, or have contraindications for MRI will not undergo MRI scanning. Contraindications include: History of neurological diseases: brain tumor, stroke, epilepsy, traumatic brain injury, multiple sclerosis, etc. Incompatible implants: cardiac pacemaker, defibrillator, certain types of aneurysm clips, cochlear implants, neurostimulators, etc. Presence of metallic foreign bodies in the body: dentures, intraorbital metallic fragments, shrapnel in certain body regions, etc. Claustrophobia.