Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis (NCT07555379) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis
United Arab Emirates40 participantsStarted 2026-09-01
Plain-language summary
The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS). The study will also look at how this treatment affects fatigue, sleep, memory and attention, and quality of life.
The main questions this study aims to answer are the following:
Does this treatment improve coordination and balance? Does it reduce fatigue and improve sleep and daily life? Does it change brain activity?
Researchers will compare active brain stimulation to sham stimulation (a look-alike treatment that does not deliver real stimulation) to see if the treatment works.
Participants will:
Receive brain stimulation sessions for two weeks Attend assessment sessions before and after treatment Return for a follow-up visit after four weeks Complete tests of movement, fatigue, sleep, and thinking
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Confirmed diagnosis of Multiple Sclerosis according to the revised McDonald criteria
* Adult Age \> 18 years
* Expanded Disability Status Scale (EDSS) score between 2.0 and 6.0
* Clinically stable disease status for at least 3 months prior to enrollment
* On stable disease-modifying therapy (DMT) for at least 3 months
* Ability to understand study procedures and provide informed consent
* Ability to ambulate independently or with assistive devices sufficient to complete motor assessments
Exclusion Criteria:
* Multiple sclerosis relapse within the past 3 months
* History of epilepsy or seizures
* Presence of implanted electronic devices (e.g., pacemaker, neurostimulator)
* Metallic implants in the head or skull incompatible with transcranial magnetic stimulation (TMS)
* Severe cognitive impairment preventing participation in assessments
* Pregnancy or planned pregnancy during the study period
* Other neurological or psychiatric disorders that may confound study outcomes
* Severe musculoskeletal or orthopedic conditions interfering with motor performance testing
* Contraindications to non-invasive brain stimulation or TMS
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Scale for the Assessment and Rating of Ataxia (SARA)
Timeframe: Baseline (within 7 days prior to the first intervention session), immediately post-intervention (within 7 days after completion of the 10-session intervention), and at 4-week follow-up.