Basement Membrane Regeneration for Wound Repair

Inclusion Criteria: * Patients with wounds requiring surgical repair (skin grafting, flap surgery, or primary suture), including but not limited to: burn wounds, traumatic wounds, post-surgical excision defects (e.g., scars, pigmentation disorders, skin tumors), and chronic wounds (diabetic ulcers, venous ulcers, pressure injuries, radiation ulcers, neuropathic ulcers, burn residual wounds, etc.). * Age (No age restriction). For minors under 18 years, informed consent must be provided by a parent or legal guardian. * Stable vital signs and able to tolerate surgery as confirmed by routine examinations. * Understand and willing to participate and able to provide signed informed consent. Exclusion Criteria: * Severe uncontrolled systemic disease or acute systemic infection, rapidly progressive or advanced disease, or severe organ dysfunction (heart, lung, brain, etc.). * Psychiatric disorder. * Presence of diseases (e.g., malignant tumor, autoimmune disease) or use of medications (e.g., high-dose corticosteroids: ≥40 mg prednisone or equivalent per day for ≥2 weeks) that may affect wound healing. * HIV positivity, clinical diagnosis of AIDS, or absolute neutrophil count (ANC) \< 1000 cells/mm³ during screening. * Pregnancy or breastfeeding. * Active infection or necrosis of the wound (unless controlled after debridement).