This study aims to investigate the chronic effects of ETAS® on cognitive, affective and neural outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.
Who can participate
Age range60 Years – 80 Years
SexALL
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Inclusion Criteria:
* Aging between 60-80 years old
* Having normal vision and hearing
* Having a body mass index between 18.5 and 30
* Having mild to moderate subjective cognitive complaints
Exclusion Criteria:
* Smoking
* Having food allergies
* Following restrictive and/or unbalanced diets (Appendix 6: Are you vegetarian or vegan? Yes / No; Are you currently on a weight-reducing or other special diet? Yes/No If 'Yes', please give details.)
* Being diagnosed with any psychiatric or neurologic conditions (e.g. schizophrenia, depression, dementia) including eating disorders
* Being diagnosed with any cardiometabolic diseases (including type II diabetes and cardiovascular disease), or hypertension or thrombosis related disorders or suffer from thyroid disease
* Currently taking anticoagulants, antiplatelet medication, antidepressants, proton-pump inhibitors
* Currently consuming prebiotic or probiotic supplements
* Continuous antibiotic use for \> 3 days within 1 month prior to enrolment
* Continuous use of weight-loss drug for \> 1 month before screening
* Having a significant gastrointestinal (GI) condition affecting absorption including (but not limited to) inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end stage renal disease; active cancer, or treatment for any cancer, in last 3 years
* History of claustrophobia
* Fitted with a pacemaker or artificial heart valve
* Have active implants, such as cochlear, ocular, or penile imp…
What they're measuring
1
Montreal Cognitive Assessment (MoCA) score
Timeframe: From baseline (pre intervention) to week 12 (post intervention)
2
fMRI
Timeframe: From baseline (pre intervention) to week 12 (post intervention)
3
MRS
Timeframe: From baseline (pre intervention) to week 12 (post intervention)