Sebum Metabolomics and Lipidomics for Clinical Applications (NCT07549828) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Sebum Metabolomics and Lipidomics for Clinical Applications
200 participantsStarted 2026-04-01
Plain-language summary
This study aims to develop a standardized workflow for sebum sampling and metabolomics/lipidomics analysis using Sebutape. A total of 200 participants will be recruited, including healthy individuals, patients with skin diseases, individuals undergoing dermatological treatments or using skincare products, and a subset of healthy participants receiving short-term topical antibiotic intervention. The study will investigate sebum composition, skin microbiome profiles, and their interactions under different conditions to explore potential biomarkers and clinical applications.
Who can participate
Age range
20 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
A. Healthy Participants
Inclusion Criteria:
* Individuals aged ≥20 years, regardless of sex or ethnicity, and assessed by the investigator to be in good health and suitable for participation.
* No diagnosed skin diseases or chronic systemic diseases.
* No use of medications or receipt of dermatological treatments that may affect sebum secretion or the skin microbiome within the past two weeks.
Exclusion Criteria:
* Known allergy to Sebutape or similar adhesive tapes, or a history of related adverse reactions.
* Presence of acute or chronic skin diseases, or chronic systemic diseases.
* Use of medications or receipt of dermatological treatments that may affect sebum secretion or the skin microbiome within the past two weeks.
* Use of lotions, sunscreen, or other skincare products that may affect skin condition within 12 hours prior to sampling.
* Any other conditions deemed unsuitable for participation by the principal investigator.
B. Participants with Skin Diseases or Specific Skin Conditions
Inclusion Criteria:
* Individuals aged ≥20 years, regardless of sex or ethnicity, and assessed by the investigator to be suitable for participation.
* Diagnosed by a physician or clinically assessed as having one of the following:
* Acne
* Atopic dermatitis
* Seborrheic dermatitis
* Psoriasis
* Other common skin diseases
* Specific skin conditions (e.g., postmenopausal or aging-related skin changes)
Exclusion Criteria:
* Known allergy to Sebutape or similar adhesiv…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Concentration of Sebum Lipids Measured by LC-MS/MS
Timeframe: From baseline (pre-intervention or pre-treatment) to post-intervention (approximately 1 day after completion of a 3-day intervention) or post-treatment (up to 3 months after treatment initiation, depending on treatment regimen)
2
Relative Abundance of Skin Microbiome Composition Assessed by Sequencing
Timeframe: From baseline (pre-intervention or pre-treatment) to post-intervention (approximately 1 day after completion of a 3-day intervention) or post-treatment (up to 3 months after treatment initiation, depending on treatment regimen)