Phase 2 Study Of Imetelstat for Patient With Myelodysplastic/Myeloproliferative Neoplasms

Eligibility Criteria * Age ≥18 years as MF and CMML are very rare diseases in the pediatric population. * Diagnosis of MDS/MPN according to WHO including: 1. CMML-1 or CMML-2 with resistance or intolerance to hydroxyurea (if myeloproliferative subtype defined by WBC \>13x109/L) or with no response or intolerance to 4 cycles of azacitidine or decitabine or relapse or progression after any number of cycles. CMML-1 Participants with Hgb \<11g/dL, TSS score 20 or splenomegaly (defined as \>5cm under the lower costal margin by physical exam or \>12cm by imaging) in which hydroxyurea or HMA therapy is not indicated will also be eligible. 2. MDS/MPN with neutrophilia (previous atypical CML) or MDS/MPN-NOS with either \>5% bone marrow blasts, Hgb \<11g/dL or requiring transfusions, platelet count \>450x109/L, TSS symptom score 20 or splenomegaly \>5cm under the lower costal margin (or \>12cm by imaging). 3. MDS/MPN with SF3B1 mutation and thrombocytosis (prior MDS/MPN-RS-T) with Hgb \<11g/dL or requiring transfusions or with platelet count \>450x109/L who have no response or failure to erythroid stimulating agents or who are unlikely to benefit due to endogenous erythropoietin levels \>500mU/mL or who have intolerance or resistance to hydroxyurea. Participants having received other prior therapies including but not limited to lenalidomide, luspatercept, JAK inhibitors or HMA will also be eligible. * ECOG performance status ≤2 * Adequate hepatic function with total bilirubin…