High-Frequency Repetitive Transcranial Magnetic Stimulation for Cognitive Improvement in Patients… (NCT07546877) | Clinical Trial Compass
RecruitingNot Applicable
High-Frequency Repetitive Transcranial Magnetic Stimulation for Cognitive Improvement in Patients With Post-Stroke Cognitive Impairment
China40 participantsStarted 2026-04-01
Plain-language summary
To clarify the clinical efficacy of high-frequency rTMS on patients with post-stroke cognitive impairment, fNIRS and EEG techniques were used to observe the changes in brain functional activities of patients with post-stroke cognitive impairment after rTMS treatment, and to clarify the neuroregulatory effect of rTMS on patients with post-stroke cognitive impairment.
Who can participate
Age range35 Years – 75 Years
SexALL
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Inclusion criteria
✓. Meets the diagnostic criteria for stroke as stipulated in the "Guidelines for the Prevention and Treatment of Stroke in China (2021 Edition)", and the initial stroke diagnosis is confirmed by cranial CT or MRI examination, and is confirmed as the initial onset;
✓. The disease course is 1-12 months;
✓. Has cognitive impairment (MoCA \< 26 points, education years ≤ 12 years, add 1 point to the score result);
✓. Age 35-75 years old, gender not limited;
✓. Stable vital signs, no progressive neurological symptoms;
✓. No severe aphasia, visual or auditory impairment, and able to complete the research protocol;
✓. Not using antidepressant drugs simultaneously;
✓. If using cognitive-improving drugs (such as donepezil, memantine), it should last for at least 3 weeks or more, and no dose adjustment will be made during the enrollment period;
Exclusion criteria
✕. Has a history of brain tumors, brain trauma, epilepsy or mental disorders;
✕. Had cognitive impairment before the stroke;
✕. Underwent craniotomy or had a skull defect;
✕. Had implanted metal or electronic devices (such as cardiac pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt surgery, etc.);
What they're measuring
1
Montreal Cognitive Assessment
Timeframe: Baseline, Day 10, Day 20,Evaluate the Montreal Cognitive Assessment Scale, fNIRS, Symbol-Digit Substitution Test, Shape Linking Test, Pittsburgh Sleep Quality Index, Digit Span Test, Stroop Test, Fugl-Meyer Assessment, Hamilton Depression Scale, Hamilton