The goal of this interventional study is to test the feasibility of 12 weeks of aerobic exercise for people with advanced multiple sclerosis (i.e., wheelchair users). The main questions it aims to answer are: * Is the exercise intervention feasible in terms of study processes, resources, management, safety, and acceptability? * Can the intervention improve aerobic fitness, function in daily life, cognition, symptoms of fatigue and pain, and sensation? * What are participants' experiences of taking part in the exercise intervention? Participants will take part in moderate-intensity aerobic exercise twice a week for 12 weeks in a supervised research setting. Outcomes will be measured at baseline (0 weeks), mid-intervention (6 weeks), post-intervention (12 weeks), and 12-weeks after the intervention (24 weeks). The outcomes include feasibility measures, aerobic fitness, function in daily life, cognition, symptoms of fatigue and pain, sensation, and participant experiences of taking part in the exercise intervention.
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Feasibility - Recruitment duration
Timeframe: Ongoing during the study recruitment period.
Feasibility - Recruitment methods
Timeframe: Ongoing during the study recruitment period.
Feasibility - Recruitment screening time
Timeframe: Ongoing during the study recruitment period.
Feasibility - Recruitment eligibility rate
Timeframe: Ongoing during the study recruitment period.
Feasibility - Recruitment exclusion reasons
Timeframe: Ongoing during the study recruitment period.
Feasibility - Adherence
Timeframe: Ongoing during the 12-week intervention.
Feasibility - Compliance frequency
Timeframe: Ongoing during the 12-week intervention.
Feasibility - Compliance duration
Timeframe: Ongoing during the 12-week intervention.
Feasibility - Compliance intensity
Timeframe: Ongoing during the 12-week intervention.
Feasibility - Attrition frequency
Timeframe: Over the course of the 24-week study period.
Feasibility - Attrition reasons
Timeframe: Over the course of the 24-week study period.
Feasibility - Time required for testing sessions
Timeframe: At each testing timepoint (Baseline, 6, 12, and 24 weeks).
Feasibility - Time required for training sessions
Timeframe: Ongoing during the 12-week intervention.
Feasibility - Personnel required
Timeframe: Over the course of the 24-week study period.
Feasibility - Personnel training completed
Timeframe: Before delivery of the 12-week intervention.
Feasibility - Time required for research ethics approval
Timeframe: Before the start of the trial.
Feasibility - Adverse events
Timeframe: Over the course of the 24-week study period (recorded at each testing and training session).
Feasibility - Acceptability of equipment
Timeframe: After the 12-week intervention.
Feasibility - Acceptability of outcomes
Timeframe: At each testing timepoint (Baseline, 6, 12 and 24 weeks).