Not Yet RecruitingPhase 2

A Phase 2 Study of JADE101 in Participants With Immunoglobulin A Nephropathy

30 participantsStarted 2026-05

Plain-language summary

This open-label Phase 2 study will characterize the safety and efficacy of JADE101 in participants with IgA nephropathy, and the results will contribute to the overall clinical characterization of JADE101 in this patient population.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Male or female participants 18-60 years of age, inclusive, and of local legal consenting age at the time of signing the informed consent
✓. eGFR ≥ 30 mL/min/1.73 m2
✓. Biopsy-confirmed primary IgAN
✓. Receiving stable and maximally tolerated doses of either ACEi or ARB as per standard of care (SoC) and applicable guidelines for at least 12 weeks prior to the initial screening visit, with no intention to alter the dose or discontinue treatment, unless medically necessary
✓. UPCR ≥ 0.75 g/g
✓. Willing to provide written informed consent
✓. Willing and able to comply with scheduled study visits, treatment plans, laboratory tests, and other study procedures
✓. Willing and able to comply with contraceptive and lifestyle requirements

Exclusion criteria

✕. Secondary forms of IgAN
✕. Known or suspected coexisting Chronic Kidney Disease (CKD) other than IgAN
✕. Known or suspected rapidly progressive glomerulonephritis (RPGN)
✕. Evidence of pathological findings in the kidney biopsy in addition to IgAN (eg, minimal change disease, diabetic kidney disease, membranous nephropathy, focal segmental glomerulosclerosis, or lupus nephritis); hypertensive vascular changes are acceptable
✕. Known or suspected primary or secondary immunodeficiency disorder
✕. Evidence of tuberculosis infection at screening
✕. Any chronic infectious disease
✕. Any acute infectious disease at time of screening

What they're measuring

Safety and tolerability of JADE101 in participants with IgA nephropathy

Timeframe: Day 1 through 100 weeks

Trial details

NCT IDNCT07541287

SponsorJade Biosciences, Inc.

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2029-01

Contact for this trial

JADE101 Study Contact

+1 781 201 4703 JADE101clinicaltrials@jadebiosciences.com

View on ClinicalTrials.gov More IgA Nephropathy trials