This study aims to evaluate and compare the clinical, biochemical, and microbiological effects of chlorhexidine and Morus nigra (blackberry) mouthwashes used as an adjunct to non-surgical periodontal treatment (scaling and root planing - SRP) in patients with periodontal diseases. The participants will be divided into three groups: a control group receiving only SRP, a group receiving SRP combined with chlorhexidine mouthwash, and a group receiving SRP combined with Morus nigra mouthwash. Clinical periodontal parameters, gingival crevicular fluid levels of inflammatory markers (including TNF-a, IL-1b, and IL-10), and subgingival plaque microbiological profiles (such as red complex bacteria and Fusobacterium) will be evaluated at baseline, 1 month, and 3 months after the treatment.
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Gingival Index (GI)
Timeframe: Baseline (Day 0), 1 month, and 3 months after periodontal treatment.
Plaque Index (PI)
Timeframe: Baseline (Day 0), 1 month, and 3 months after periodontal treatment.
Probing Depth (PD)
Timeframe: Baseline (Day 0), 1 month, and 3 months after periodontal treatment.
Clinical Attachment Level (CAL)
Timeframe: Baseline (Day 0), 1 month, and 3 months after periodontal treatment.
Bleeding on Probing (BOP)
Timeframe: Baseline (Day 0), 1 month, and 3 months after periodontal treatment.