Evaluation of the Safety, Feasibility, and Early Clinical Outcomes of Patient-Specific Bone Defect Implants Fabricated From Titanium Alloy (Ti-6Al-4V) Using 3D Printing Technology

Inclusion Criteria: * Diagnosed with a bone defect requiring surgical reconstruction, as determined by the treating orthopedic surgeon * Suitable candidate for implantation of a patient-specific device manufactured from Ti-6Al-4V * Able to undergo preoperative imaging (CT ± MRI) required for implant design * Willing and able to provide written informed consent * Willing to comply with scheduled follow-up visits and study assessments Exclusion Criteria: * Active systemic or local infection at the surgical site at the time of implantation * Known hypersensitivity or allergy to titanium or titanium alloys * Severe uncontrolled comorbidities that significantly increase surgical risk (e.g., uncontrolled diabetes, severe cardiovascular disease) * Pregnant or breastfeeding women * Participation in another interventional clinical study that may interfere with the outcomes of this study * Inability to complete follow-up assessments within the required timeframe