High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in High-altitude Pulmon… (NCT07536477) | Clinical Trial Compass
RecruitingNot Applicable
High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema
China200 participantsStarted 2026-04-25
Plain-language summary
This study aims to evaluate whether High-flow Nasal Cannula Oxygen Therapy (HFNC) provides superior respiratory support compared to Conventional Oxygen Therapy (COT) in patients with High-Altitude Pulmonary Edema (HAPE).
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Aged 18 years or older;
✓. Onset of symptoms related to HAPE (including dyspnea at rest, cough, or exercise intolerance) within 7 days of ascending to high altitude (≥2500m);
✓. Diagnosis of HAPE according to the STAR data reporting guidelines, requiring at least two symptoms (dyspnea at rest, cough, weakness/decreased exercise performance, or chest tightness/congestion) and two clinical signs (rales or wheezing in at least one lung field, central cyanosis, tachypnea, or tachycardia);
✓. Radiographic evidence of pulmonary edema on chest X-ray or CT;
✓. Refusal or inability to undergo immediate descent at the time of presentation;
✓. Capability and willingness to provide written informed consent.
Exclusion criteria
✕. Known or clinically confirmed pregnancy;
✕. Requirement for emergency intubation (as assessed by the treating clinician) due to cardiac/respiratory arrest, hemodynamic instability, airway compromise, severe hypoxia, or impaired consciousness, etc;
✕. Pulmonary edema or hypoxemia resulting from other medical conditions (e.g., cardiogenic pulmonary edema, sepsis, chronic obstructive pulmonary disease (COPD), pneumothorax, massive pleural effusion, chest trauma, etc.);
✕. Glasgow Coma Scale (GCS) score ≤ 12;
✕. PaCO₂ \> 55 mmHg;
What they're measuring
1
Time to weaning off supplemental oxygen
Timeframe: From date of randomization to oxygen therapy completion (oxygen weaning), an average of 3-5 days.