Biologic Augmentation of TMJ Arthroscopy Using BMAC (NCT07536399) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Biologic Augmentation of TMJ Arthroscopy Using BMAC
United States20 participantsStarted 2026-04
Plain-language summary
The goal of this clinical trial is to learn about the efficacy of using Bone Marrow Aspirate Concentrate (BMAC) during temporomandibular joint (TMJ) arthroscopy compared to standard arthroscopic procedures with corticosteroid (CS) injections in patients with pain (arthralgia) of the temporomandibular joint (TMJ) that has failed to respond to conservative treatment. The main question it aims to answer:
Does BMAC injection reduce the amount of inflammation and structural damage in the TMJ? Researchers will compare BMAC injection to corticosteroid injections see if BMAC injection helps .
Participants will :
* Be randomized to receive either BMAC or CS injection during TMJ arthroscopy
* Visit the clinic for 3 follow up visits over 6 months and answer questionnaires
* have 2 MRIs of their jaw
Who can participate
Age range18 Years – 75 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Participant is at least 18 years of age and not older than 75 years of age
✓. Participant is willing and able to provide written informed consent to participant in this study
✓. Participant has symptoms of TMJ arthralgia (pain) with significant temporomandibular joint pain and dysfunction despite at least 30 days of conservative therapy (NSAIDS, muscle relaxants, bite splints, PT, warm compresses, soft diet, etc.)
✓. Participant has baseline pain of ≥30 on a 100mm visual analog scale (VAS)
Exclusion criteria
✕. Participant has not competed at least 30 days of conservative therapy
✕. Participant was diagnosed with central or neuropathic pain disorder
✕. Participant has a primary diagnosis of myofascial pain
✕. Participant has fibromyalgia
✕. Participant is pregnant or breastfeeding
What they're measuring
1
Change from Baseline in Kellenberger score at 6 Months.
Timeframe: Baseline; 6 months
Trial details
NCT IDNCT07536399
SponsorWeill Medical College of Cornell University