A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pai… (NCT07533786) | Clinical Trial Compass
RecruitingPhase 2
A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Abdominal Surgery
China200 participantsStarted 2026-05-22
Plain-language summary
This is a multi-center, randomized, double-blind, double-dummy, placebo/active-controlled study. 200 subjects undergoing abdominal surgery under general anesthesia are planned to be enrolled and randomized into the HSK55718 group, morphine group, and placebo group.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years old, regardless of gender;
* 18 kg/m2≤BMI≤30 kg/m2;
* American Society of Anesthesiologists (ASA) gradeⅰ-ⅲ;
* Accept abdominal surgery under general anesthesia;
* Within 4 hours after the end of surgery, NRS≥4 in the resting state at any time;
* Fully understand and voluntarily participate this trial, and sign the informed consent form;
Exclusion Criteria:
* A history of cardiovascular, respiratory, neurological, or psychiatric diseases that meet the protocol-defined exclusion criteria.
* Clinically significant abnormalities in laboratory tests during the screening period.
* A history of severe drug allergy or known allergy to the investigational drug.
* Continuous use of opioid analgesics for more than 10 days for any reason within 3 months prior to randomization.
* Use of any medication that may affect analgesia, where the last dose was administered less than 5 half-lives of that drug before randomization.
* A history of drug abuse, substance abuse, and/or alcohol abuse within the past year.
* Pregnant or lactating women.
* Participation in another drug clinical trial within 3 months prior to the screening period.
* Presence of any sensory dysfunction.
* Presence of any painful physical condition.
* Subjects with any other factor considered by the investigator to be ineligible for participation in the trial.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.