Preoperative Topical Lidocaine Versus Intravenous Fentanyl to Obtund the Stress of Intubation Und… (NCT07533643) | Clinical Trial Compass
CompletedNot Applicable
Preoperative Topical Lidocaine Versus Intravenous Fentanyl to Obtund the Stress of Intubation Under Anesthesia.
Egypt50 participantsStarted 2025-08-01
Plain-language summary
To compare the effectiveness of preoperative combined topical airway anesthesia consisting of nebulised, mouth rinsing and gargling with lidocaine versus intravenous fentanyl to prevent the stress of endotracheal intubation by direct laryngoscopy under general anesthesia.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion Criteria:
* American society of anaesthesiologists class 1 or 2 (ASA 1 or 2) patients.
* Patients undergoing elective surgeries under general anaesthesia with endotracheal intubation using direct laryngoscope.
* Population aged from 18 to 60 years.
Exclusion Criteria:
* Patient's refusal to participate.
* ASA class 3 or more patients including Substantive functional limitations; One or more moderate to severe diseases. Poorly controlled DM or HTN, COPD, morbid obesity (BMI ≥40), active hepatitis, alcohol dependence or abuse, implanted pacemaker, reduction of ejection fraction, ESRD undergoing regularly scheduled dialysis, history of MI, CVA, TIA, or CAD/stents, asthma with exacerbation, poorly controlled epilepsy.
* Patients with any degree of Hypertension or treated for hypertension.
* Pregnant patients.
* Age of participant less than 18 or more than 60 years.
* History of allergy to local anaesthetics or opioids.
* Opioid abuse
* Anticipated difficult airway which will be defined as El-Ganzouri Risk Index (EGRI) score of 4 or more points.
* Difficult intubation which will be defined as situation where proper insertion of the tracheal tube with conventional laryngoscopy requires more than three attempts or more than 10 min.
* Difficult mask ventilation which will be defined as a situation that develops when it is not possible for the unassisted anaesthesiologist to maintain the oxygen saturation \>90% using 100% oxygen and positive pressure ventilation, or to pr…
What they're measuring
1
Maximum change in systolic blood pressure 5 minutes after endotracheal intubation from the baseline in both groups.