A Single Ascending Dose Study of SYH2082 Injection in Healthy Participants

Exclusion criteria

• ✕. Systolic blood pressure (SBP) \< 160 mmHg, diastolic blood pressure (DBP) \< 100 mmHg;
• ✕. Fasting TG ≤ 5.6 mmol/L, fasting TC ≤ 7.5 mmol/L, fasting LDL-C ≤ 5 mmol/L, and abnormal fasting HDL-C;
• ✕. Alanine aminotransferase (ALT) \< 2 × ULN, aspartate aminotransferase (AST) \< 2 × ULN, gamma-glutamyl transferase (GGT) \< 2.5 × ULN, and total bilirubin (TBIL) \< 1.5 × ULN. Participants with values outside the normal range may be included if the abnormality is deemed benign by the investigator (e.g., Gilbert's syndrome);
• ✕. Calcitonin ≥25 ng/L;
• ✕. Estimated glomerular filtration rate (eGFR) \<80 mL/min/1.73m2
• ✕. Thyroid-stimulating hormone (TSH) outside the normal reference range;
• ✕. Fasting serum amylase and/or lipase \>1.5× ULN.