Comparison Between Liquid Fibrin and Soft Laser Effects on Healing and Relapse After Lip Repositi… (NCT07532161) | Clinical Trial Compass
RecruitingNot Applicable
Comparison Between Liquid Fibrin and Soft Laser Effects on Healing and Relapse After Lip Repositioning Surgery
Syria22 participantsStarted 2026-04-20
Plain-language summary
A gummy smile can negatively affect a patient's self-confidence and satisfaction with their appearance, leading many individuals to seek effective esthetic solutions. The etiology of this condition varies and may include vertical maxillary excess, short upper lip, hyperactive upper lip, gingival enlargement, or altered passive eruption.
Lip Repositioning Surgery is one of the minimally invasive esthetic surgical procedures used to reduce the amount of gingival display during smiling. Despite its effectiveness, this surgery may be associated with challenges such as pain, swelling, delayed wound healing, and the possibility of postoperative relapse over time, which could compromise both esthetic and functional outcomes.
To overcome these challenges and enhance surgical outcomes, adjunctive techniques have been introduced to promote healing and determine whether enhancing the biological healing process can reduce the rate of relapse after LRS. Among the most prominent of these are Injectable Platelet-Rich Fibrin (i-PRF) and Low-Level Laser Therapy (LLLT).
Who can participate
Age range18 Years – 50 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Patients of both genders.
✓. Patients presenting with a gummy smile in the maxillary anterior region (more than 3 mm) due to upper lip hypermobility.
✓. Age 18-50 years.
✓. Systemically healthy individuals, classified as ASA physical status I or II according to the American Society of Anesthesiologists (ASA) classification; that is, patients without systemic disease or with mild, well-controlled systemic conditions.
✓. Patients with good oral hygiene, defined as an O'Leary Plaque Index ≤ 40%.
✓. No previous lip repositioning surgery.
Exclusion criteria
✕. Pregnancy and lactation.
✕. Individuals with a previous history of receiving facial Botox or filler injections.
✕. Systemic diseases or conditions that contraindicate the use of local anesthesia.
What they're measuring
1
Gingival display (mm)
Timeframe: Baseline and 1, 3 and 6 months postoperatively