This randomized controlled clinical trial aims to evaluate the clinical, radiographic, and ultrasonographic outcomes of alveolar ridge preservation using autologous blood products following tooth extraction.
After tooth extraction, dimensional changes occur in both hard and soft tissues, which may negatively affect future implant or prosthetic treatments. This study investigates whether the application of Titanium Platelet-Rich Fibrin (T-PRF), combined with injectable Platelet-Rich Fibrin (i-PRF), can improve healing and reduce tissue changes.
In this study, tooth extraction will be performed under local anesthesia using minimally invasive techniques. Autologous blood will be collected from the patient and processed by centrifugation to obtain T-PRF and i-PRF. The prepared materials will be applied to the extraction socket and stabilized with sutures. Healing will be monitored through clinical examinations, radiographic imaging, and ultrasonographic evaluations over a 6-month follow-up period.
Possible risks include pain, bleeding, infection, and temporary discomfort, all of which are manageable with standard clinical care.
The study is expected to contribute to the development of biologically based, minimally invasive treatment approaches that enhance tissue healing and support future dental treatments.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Systemically healthy individuals with no medical conditions that could interfere with periodontal treatment, tooth extraction, or wound healing
* Absence of systemic diseases affecting blood coagulation and no use of anticoagulant medications
* No history of blood-borne infectious diseases
* Non-smokers
* Age ≥18 years
* Patients requiring extraction of a single-rooted tooth in the maxilla or mandible
* Availability of a pre-existing CBCT scan of the planned extraction site
* Extraction site suitable for implant placement
Exclusion Criteria:
* Presence of systemic diseases that may affect periodontal treatment, tooth extraction, wound healing, or increase the risk of complications
* Presence of bleeding or coagulation disorders, or use of anticoagulant therapy
* Presence of blood-borne infectious diseases
* Smoking habit
* Age \<18 years
* Psychological or mental conditions that may affect compliance with treatment or study participation
* Extraction sites not suitable for implant placement
* History of previous surgical intervention or compromised healing in the extraction site
* Pregnancy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.